Evidence map›Paper›PMID 33414790›Full record

ReviewFrontiers in immunology2020

RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?

Jonas B Sandbrink, Robin J Shattock

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Research progress of mRNA vaccines for infectious diseases.European journal of medical research · 2025
    Review
  4. The role of mRNA vaccines in infectious diseases: a new era of immunization.Tropical diseases, travel medicine and vaccines · 2025
    Review
  5. Preclinical development of lyophilized self-replicating RNA vaccines for COVID-19 and malaria with improved long-term thermostability.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. RNA modification in mRNA cancer vaccines.Clinical and experimental medicine · 2023
    Review
  13. Review
  14. From Immunogen to COVID-19 vaccines: Prospects for the post-pandemic era.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  15. Review
  16. Self-Amplifying RNA Approach for Protein Replacement Therapy.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Review
  19. Review
  20. Covid-19 vaccines and variants of concern: A review.Reviews in medical virology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jonas B SandbrinkMedical School, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Robin J ShattockDepartment of Infectious Diseases, Imperial College London, London, United Kingdom.
Imperial College London · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challenge. The use of an RNA-based delivery mechanism promises fast vaccine development, clinical approval, and production. The simplicity of

Indexed as

RNA, MessengerVaccines, DNAAnimalsHumansPandemicsRNA, MessengerVaccines, DNAinfectious diseasemRNA vaccineoutbreakpandemicsself-amplifying RNAvaccine developmentvaccine platform

Identifiers

PMID33414790
PMCPMC7783390
OpenAlexW3115710812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.