Evidence map›Paper›PMID 33414789›Full record

ArticleFrontiers in immunology2020

Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy.

Dylan Krajewski, Stephanie H Polukort, Justine Gelzinis, Jeffrey Rovatti, Edwin Kaczenski, Christine Galinski, Megan Pantos, Nickul N Shah, Sallie S Schneider, Daniel R Kennedy and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Targeting thiol isomerase activity with zafirlukast to treat ovarian cancer from the bench to clinic.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  8. Review
  9. Effect of Ginger on Inflammatory Diseases.Molecules (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Dylan KrajewskiDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Stephanie H PolukortDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Justine GelzinisDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Jeffrey RovattiDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Edwin KaczenskiDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Christine GalinskiDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Megan PantosDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Nickul N ShahPioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA, United States.
Sallie S SchneiderPioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA, United States.
Daniel R KennedyDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Clinton B MathiasDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, United States.
Western New England University · USBaystate Medical Center · USPioneer (United States) · US

Funding

Response to PQ12 - Using thiol isomerase inhibitors to diminish cancer induced thrombosisR21CA231000 · NCI · WESTERN NEW ENGLAND UNIVERSITY · PI KENNEDY, DANIEL ROBERT, PATELL, RUSHAD · 2019 to 2021
$377k
Inhibitory effects of curcumin on Th2 sensitization and mast cell function in a mR15AI107668 · NIAID · WESTERN NEW ENGLAND UNIVERSITY · PI MATHIAS, CLINTON B · 2014 to 2014
$348k
NCI NIH HHS R21 CA231000NIAID NIH HHS R15 AI107668
6 · The paper itself

Abstract

The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability. Recent studies suggest novel roles for extracellular cell surface PDI in enhancing cellular activation and promoting their function. Moreover, a number of food-derived substances have been shown to regulate cellular PDI activity and alter disease progression. We hypothesized that PDI may have similar roles during mast cell-mediated allergic responses and examined its effects on IgE-induced mast cell activity during cell culture and food allergy. Mast cells were activated

Indexed as

AnimalsAnti-Allergic AgentsBacitracinCell DegranulationCell ProliferationCells, CulturedCurcuminCytokinesDiarrheaDisease Models, AnimalEnzyme InhibitorsFood HypersensitivityImmunoglobulin EIntestinesMast CellsMice, Inbred BALB CAnti-Allergic AgentsBacitracinCurcuminCytokinesEnzyme InhibitorsImmunoglobulin EOvalbuminProtein Disulfide-IsomerasesRutinfood allergymast cellsPDIpropynoic acid carbamoyl methyl amideprotein disulfide isomerase

Identifiers

PMID33414789
PMCPMC7783394
OpenAlexW3115857941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.