Evidence map›Paper›PMID 33414700›Full record

ArticleFrontiers in neuroscience2020

Case Report: Concurrent Resistance and Aerobic Training Regulate Adiponectin Expression and Disease Severity in Multiple Sclerosis: A Case Study.

Elisa Grazioli, Ersilia Nigro, Claudia Cerulli, Giovanna Borriello, Annamaria Mancini, Eliana Tranchita, Rita Polito, Attilio Parisi, Pasqualina Buono, Aurora Daniele

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elisa GrazioliDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy.
Ersilia NigroDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, Italy.
Claudia CerulliDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy.
Giovanna BorrielloDepartment of Neurological Sciences, Sapienza University of Rome, Rome, Italy.
Annamaria ManciniDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Eliana TranchitaDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy.
Rita PolitoCEINGE Advanced Biotechnologies, Naples, Italy.
Attilio ParisiDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy.
Pasqualina BuonoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Aurora DanieleDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, Italy.
Foro Italico University of Rome · ITCeinge Biotecnologie Avanzate (Italy) · ITSapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adapted exercise is an effective non-pharmacological tool to improve functional, cognitive, and psychological parameters in multiple sclerosis (MS), in association with increased quality of life (QoL) and decreased disease severity. Adipose tissue, through the production of different adipokines, is involved in regulating energy metabolism and inflammation. Adiponectin, increased in MS, circulates as oligomers of low (LMW), medium (MMW), and high molecular weight (HMW), the latter mediating the main biological effects. The aim of study was to evaluate the effects of 4 months training at moderate intensity [65% heart rate reserve (HRR)] on BMI, adiponectin, and QoL in a volunteer with secondary progressive MS. The parameters were evaluated before (T0), after 4 months training (T1), and 6 months after the end of training (T2); total serum adiponectin and its oligomeric profile were evaluated. We found a reduction in BMI (-0.9%) and FAT (-2.6%), an improvement in perceived QoL and a reduced expression of total adiponectin and HMW oligomers together with decreased MS disability level at T1 measured by EDSS. Despite the limitations of a case study, this represent a starting point to understand the influence of exercise in MS and the relationship with adiponectin expression.

Indexed as

adiponectinEDSSHMW oligomersmultiple sclerosistraining

Identifiers

PMID33414700
PMCPMC7783198
OpenAlexW3115761101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.