Evidence map›Paper›PMID 33414569›Full record

ArticleComputer methods in applied mechanics and engineering2021

Non-invasive Inference of Thrombus Material Properties with Physics-Informed Neural Networks.

Minglang Yin, Xiaoning Zheng, Jay D Humphrey, George Em Karniadakis

Abstract read
In one paragraph

Article in Computer methods in applied mechanics and engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Article
  6. Article
  7. From PINNs to PIKANs: recent advances in physics-informed machine learning.Machine learning for computational science and engineering · 2025
    Article
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  13. Review
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  18. Machine Learning and the Conundrum of Stroke Risk Prediction.Arrhythmia & electrophysiology review · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Minglang YinCenter for Biomedical Engineering, Brown University, Providence, RI 02912.
Xiaoning ZhengDivision of Applied Mathematics, Brown University, Providence, RI 02912.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520.
George Em KarniadakisDivision of Applied Mathematics, Brown University, Providence, RI 02912.

Funding

Multimodality imaging-driven multifidelity modeling of aortic dissectionU01HL142518 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., KARNIADAKIS, GEORGE · 2018 to 2022
$2.8M
NHLBI NIH HHS U01 HL142518
6 · The paper itself

Abstract

We employ physics-informed neural networks (PINNs) to infer properties of biological materials using synthetic data. In particular, we successfully apply PINNs on inferring permeability and viscoelastic modulus from thrombus deformation data, which can be described by the fourth-order Cahn-Hilliard and Navier-Stokes Equations. In PINNs, the partial differential equations are encoded into a loss function, where partial derivatives can be obtained through automatic differentiation (AD). In addition to tackling the challenge of calculating the fourth-order derivative in the Cahn-Hilliard equation with AD, we introduce an auxiliary network along with the main neural network to approximate the second-derivative of the energy potential term. Our model can simultaneously predict unknown material parameters and velocity, pressure, and deformation gradient fields by merely training with partial information among all data, i.e., phase field and pressure measurements, while remaining highly flexible in sampling within the spatio-temporal domain for data acquisition. We validate our model by numerical solutions from the spectral/

Indexed as

Computational Fluids DynamicsInverse ProblemPhase Field ModelPhysics-informed Neural NetworksViscoelastic Porous Material

Identifiers

PMID33414569
PMCPMC7785048

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.