ArticleNature genetics2021
A cross-platform approach identifies genetic regulators of human metabolism and health.
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Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
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137citing papers in PubMed, 8 pooled it
14.4field-weighted citation impact, top 1% of its field
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Who cites it
137 citing papers in PubMed, 8 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.Functional & integrative genomics · 2026Pooled it
- Use of Mendelian Randomization to Unveil Metabolic Markers inJournal of Korean medical science · 2026Pooled it
- Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes.Diabetes, obesity & metabolism · 2026Pooled it
- Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.Cell genomics · 2025Pooled it
- An atlas of genome-wide gene expression and metabolite associations and possible mediation effects towards body mass index.Journal of molecular medicine (Berlin, Germany) · 2023Pooled it
- Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.Nature communications · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study.Kidney international · 2022Pooled it
- Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.Circulation research · 2022Trial
- Expanding the pig metabolomics QTL catalog.Genetics, selection, evolution : GSE · 2026Article
- Phenylalanine primes renal tubular redox vulnerability and calcium oxalate crystal retention through a PPARδ-CPT1A fatty-acid oxidation axis.Redox biology · 2026Article
- Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk.Nature genetics · 2026Article
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism.bioRxiv : the preprint server for biology · 2026Article
- African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.Genome medicine · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues.American journal of human genetics · 2026Article
- Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.Nature medicine · 2026Article
- Integration of metabolomic and genetic data reveals novel variants underpinning the human metabolome: the Coronary Artery Risk Development in Young Adults (CARDIA) study.medRxiv : the preprint server for health sciences · 2026Article
- LiMA: Robust inference of molecular mediation from summary statistics.American journal of human genetics · 2026Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 9 institutions in 4 countries.
Luca A Lotta *MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Maik Pietzner *MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Isobel D StewartMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Laura B L WittemansMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Chen LiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Roberto BonelliPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Johannes RafflerInstitute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-2495-4020
Emma K BiggsMetabolic Research Laboratories, University of Cambridge, Cambridge, UK.
Clare Oliver-WilliamsBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Victoria P W AuyeungMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0823-3963
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3137-6337
Eleanor WheelerMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8616-6444
Ellie PaigeNational Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia.ORCID http://orcid.org/0000-0003-0855-9872
Praveen SurendranBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Gregory A MichelottiMetabolon Inc, Durham, NC, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3634-3016
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5365-8760
Verena ZuberMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9827-1877
Eleanor SandersonMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-5188-5775
Albert KoulmanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9998-051X
Fumiaki ImamuraMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6841-8396
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5041-248X
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
MacTel Consortium
Julian L GriffinBiomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Angela M WoodBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Gabi KastenmüllerInstitute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-2368-7322
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Fiona M GribbleMetabolic Research Laboratories, University of Cambridge, Cambridge, UK.
Frank ReimannMetabolic Research Laboratories, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9399-6377
Melanie BahloPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-5132-0774
Eric FaumanInternal Medicine Research Unit, Pfizer Worldwide Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9739-0249
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1422-2993
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, UK. claudia.langenberg@mrc-epid.cam.ac.uk.ORCID http://orcid.org/0000-0002-5017-7344
University of Cambridge · GBHelmholtz Zentrum München · DEThe University of Melbourne · AUAustralian National University · AUImperial College London · GBMetabolon (United States) · USPfizer (United States) · USUniversity of Bristol · GBWellcome/MRC Institute of Metabolic Science · GB
Funding
British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946British Heart Foundation SP/09/002Cancer Research UK 14136Cancer Research UK C864/A14136Chief Scientist OfficeDepartment of Health BTRU-2014-10024Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G1000143Medical Research Council MC_PC_13030Medical Research Council MC_PC_13046Medical Research Council MC_PC_13048Medical Research Council MC_UP_A090_1006Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00011/2Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Medical Research Council MC_UU_12015/1Medical Research Council MR/L00002/1Medical Research Council MR/L003120/1Medical Research Council MR/N003284/1Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1Medical Research Council MR/S003746/1Medical Research Council MR/S019669/1Wellcome Trust 106262/Z/14/ZWellcome Trust 106263/Z/14/ZWellcome Trust 204623Wellcome Trust 204623/Z/16/ZWellcome Trust WT083442AIA
Abstract
In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10
Indexed as
HealthDiabetes Mellitus, Type 2Eye DiseasesGene FrequencyGenetic LociGenetic PleiotropyGenome, HumanGlucagon-Like Peptide-2 ReceptorGlycineHumansLinear ModelsMendelian Randomization AnalysisMetabolismMetabolism, Inborn ErrorsMetabolomeMutation, MissenseGLP2R protein, humanGlucagon-Like Peptide-2 ReceptorGlycineSerine
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