Evidence map›Paper›PMID 33414529›Full record

ReviewEye (London, England)2021

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Darren Shu Jeng Ting, Charlotte Shan Ho, Rashmi Deshmukh, Dalia G Said, Harminder S Dua

Erratum issued Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05620264 (Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment), which is not on this map. Cited by 260 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 6 pooled it
60.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05620264 unknown statusnot on this mapstarted 2022, after this paper: background citation

Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment

Typeobservational_patient_registrySponsorJohannes Kepler University of LinzRan2022 to 2024Enrolled392ConditionsKeratitis Bacterial, Keratitis FungalArmsTear Sample Probe
3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 6 syntheses or guidelines pooled it, 459 citations in OpenAlex.

  1. Pooled it
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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Darren Shu Jeng Ting *Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0003-1081-1141
Charlotte Shan Ho *Department of Ophthalmology, Queen's Medical Centre, Nottingham, UK.ORCID http://orcid.org/0000-0003-1131-1448
Rashmi DeshmukhDepartment of Ophthalmology, Queen's Medical Centre, Nottingham, UK.
Dalia G SaidAcademic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.
Harminder S DuaAcademic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK. profdua@gmail.com.ORCID http://orcid.org/0000-0002-4683-6917
University of Nottingham · GBQueen's Medical Centre · GB

Funding

Fight for Sight UK MR/T001674/1RCUK | Medical Research Council (MRC) MR/T001674/1
6 · The paper itself

Abstract

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5-2.0 million new cases of monocular blindness per year, highlighting an ongoing uncurbed burden on human health. Among all aetiologies such as infection, trauma, inflammation, degeneration and nutritional deficiency, infectious keratitis (IK) represents the leading cause of corneal blindness in both developed and developing countries, with an estimated incidence ranging from 2.5 to 799 per 100,000 population-year. IK can be caused by a wide range of microorganisms, including bacteria, fungi, virus, parasites and polymicrobial infection. Subject to the geographical and temporal variations, bacteria and fungi have been shown to be the most common causative microorganisms for corneal infection. Although viral and Acanthamoeba keratitis are less common, they represent important causes for corneal blindness in the developed countries. Contact lens wear, trauma, ocular surface diseases, lid diseases, and post-ocular surgery have been shown to be the major risk factors for IK. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though its effectiveness is being challenged by the emergence of antimicrobial resistance, including multidrug resistance, in some parts of the world. In this review, we aim to provide an updated review on IK, encompassing the epidemiology, causative microorganisms, major risk factors and the impact of antimicrobial resistance.

Indexed as

Acanthamoeba KeratitisAnti-Bacterial AgentsCorneaDrug Resistance, BacterialHumansRisk FactorsAnti-Bacterial Agents

Identifiers

PMID33414529
PMCPMC8102486
OpenAlexW3120127585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.