Evidence map›Paper›PMID 33414524›Full record

ArticleMucosal immunology2021

Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection.

Verena Kästele, Johannes Mayer, Edward S Lee, Natalie Papazian, John J Cole, Vuk Cerovic, Gabrielle Belz, Michio Tomura, Gerard Eberl, Carl Goodyear and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

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  17. In Vivo Tracking of Dendritic Cell Migration.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. ILCs-Crucial Players in Enteric Infectious Diseases.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 7 countries.

Verena KästeleInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-0433-6989
Johannes MayerInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Edward S LeeDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Natalie PapazianDepartment of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
John J ColeInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Vuk CerovicWalter+Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Gabrielle BelzInstitute of Molecular Medicine, University Hospital, RWTH Aachen, Aachen, Germany.
Michio TomuraOsaka Ohtani University, Osaka, Japan.
Gerard EberlMicroenvironment & Immunity Unit, Institut Pasteur, Paris, France.
Carl GoodyearInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Rose A MaciewiczInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Daniel WallInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Tom CupedoDepartment of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
David R WithersInstitute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Simon MillingInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. Simon.Milling@glasgow.ac.uk.
University of Glasgow · GBErasmus MC · NLAlbert Einstein College of Medicine · USInstitut Pasteur · FROsaka Ohtani University · JPRWTH Aachen University · DEUniversity of Birmingham · GBWalter and Eliza Hall Institute of Medical Research · AU

Funding

Medical Research Council MR/K021095/1Medical Research Council MR/T030879/1Versus Arthritis 20298Wellcome Trust
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are enriched in mucosae and have been described as tissue-resident. Interestingly, ILCs are also present within lymph nodes (LNs), in the interfollicular regions, the destination for lymph-migratory cells. We have previously shown that LN ILCs are supplemented by peripheral tissue-derived ILCs. Using thoracic duct cannulations, we here enumerate the intestinal lymph ILCs that traffic from the intestine to the mesenteric LNs (MLNs). We provide, for the first time, a detailed characterisation of these lymph-migratory ILCs. We show that all ILC subsets migrate in lymph, and while global transcriptional analysis reveals a shared signature with tissue-resident ILCs, lymph ILCs express migration-associated genes including S1PRs, SELL (CD62L) and CCR7. Interestingly, we discovered that while Salmonella Typhimurium infections do not increase the numbers of migrating ILCs, infection changes their composition and cytokine profile. Infection increases the proportions of RORyt

Indexed as

AnimalsCell MovementDisease Models, AnimalGene Expression ProfilingHumansImmunity, InnateInterferon-gammaIntestinal MucosaLymphLymph NodesLymphocytesMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3Salmonella InfectionsInterferon-gammaNuclear Receptor Subfamily 1, Group F, Member 3

Identifiers

PMID33414524
PMCPMC8075955
OpenAlexW3118495573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.