Evidence map›Paper›PMID 33414477›Full record

ArticleNPJ Regenerative medicine2021

ILB

Lisa J Hill, Hannah F Botfield, Ghazala Begum, Omar Qureshi, Vasanthy Vigneswara, Imran Masood, Nicholas M Barnes, Lars Bruce, Ann Logan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Lisa J HillSchool of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0001-8431-7029
Hannah F BotfieldNeuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-4564-0282
Ghazala BegumNeuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Omar QureshiSchool of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Vasanthy VigneswaraSchool of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Imran MasoodSchool of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Nicholas M BarnesSchool of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Lars BruceTikoMed AB, P.O. Box 81, 263 03, Viken, Sweden.
Ann LoganAxolotl Consulting Ltd., Droitwich, Worcestershire, WR9 0JS, UK. a.logan@axolotlconsulting.com.ORCID http://orcid.org/0000-0003-3215-5042
University of Birmingham · GBTikomed (Sweden) · SEUniversity of Warwick · GB

Funding

Medical Research Council MC_PC_17169
6 · The paper itself

Abstract

Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics. Compromised cellular and tissue repair processes following injury, infection, metabolic dysfunction, autoimmune conditions and vascular diseases leave tissues susceptible to unresolved inflammation, fibrogenesis, loss of function and scarring. There has been limited clinical success with therapies for inflammatory and fibrotic diseases such that there remains a large unmet therapeutic need to restore normal tissue homoeostasis without detrimental side effects. We investigated the effects of a newly formulated low molecular weight dextran sulfate (LMW-DS), termed ILB

Identifiers

PMID33414477
PMCPMC7791102
OpenAlexW3119843470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.