Evidence map›Paper›PMID 33414470›Full record

ArticleNature communications2021

Optimal COVID-19 quarantine and testing strategies.

Chad R Wells, Jeffrey P Townsend, Abhishek Pandey, Seyed M Moghadas, Gary Krieger, Burton Singer, Robert H McDonald, Meagan C Fitzpatrick, Alison P Galvani

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 4 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 4 syntheses or guidelines pooled it, 226 citations in OpenAlex.

  1. Pooled it
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  12. Optimizing the detection of emerging infections using mobility-based spatial sampling.International journal of applied earth observation and geoinformation : ITC journal · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Environmentally persistent free radicals in PMJournal of environmental sciences (China) · 2024
    Article
  19. Review
  20. Effectiveness of SARS-CoV-2 testing strategies: A scoping review.Cochrane evidence synthesis and methods · 2023
    Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Chad R WellsCenter for Infectious Disease Modeling and Analysis (CIDMA), Yale School of Public Health, New Haven, CT, 06520, USA.
Jeffrey P TownsendDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06510, USA. Jeffrey.Townsend@Yale.edu.ORCID 0000-0002-9890-3907
Abhishek PandeyCenter for Infectious Disease Modeling and Analysis (CIDMA), Yale School of Public Health, New Haven, CT, 06520, USA.ORCID 0000-0003-4578-7487
Seyed M MoghadasAgent-Based Modelling Laboratory, York University, Toronto, ON, M3J 1P3, Canada.
Gary KriegerNewFields E&E, Boulder, CO, 80301, USA.
Burton SingerEmerging Pathogens Institute, University of Florida, P.O. Box 100009, Gainesville, FL, 32610, USA.
Robert H McDonaldGroup Health, Safety and Environment; BHP, Melbourne, VIC, 3000, Australia.
Meagan C FitzpatrickCenter for Infectious Disease Modeling and Analysis (CIDMA), Yale School of Public Health, New Haven, CT, 06520, USA.
Alison P GalvaniCenter for Infectious Disease Modeling and Analysis (CIDMA), Yale School of Public Health, New Haven, CT, 06520, USA.ORCID 0000-0002-2059-6716
Yale University · USBHP (Australia) · AUUniversity of Colorado Anschutz Medical Campus · USUniversity of Florida · USUniversity of Maryland, Baltimore · USYork University · CA

Funding

Impacts of Individual and Social Behavior on Influenza Dynamics and ControlU01GM087719 · NIGMS · YALE UNIVERSITY · PI GALVANI, ALISON P, MEYERS, LAUREN ANCEL · 2009 to 2018
$6.3M
CIHR OV4-170643NIGMS NIH HHS U01 GM087719
6 · The paper itself

Abstract

For COVID-19, it is vital to understand if quarantines shorter than 14 days can be equally effective with judiciously deployed testing. Here, we develop a mathematical model that quantifies the probability of post-quarantine transmission incorporating testing into travel quarantine, quarantine of traced contacts with an unknown time of infection, and quarantine of cases with a known time of exposure. We find that testing on exit (or entry and exit) can reduce the duration of a 14-day quarantine by 50%, while testing on entry shortens quarantine by at most one day. In a real-world test of our theory applied to offshore oil rig employees, 47 positives were obtained with testing on entry and exit to quarantine, of which 16 had tested negative at entry; preventing an expected nine offshore transmission events that each could have led to outbreaks. We show that appropriately timed testing can make shorter quarantines effective.

Indexed as

QuarantineContact TracingCOVID-19HumansModels, TheoreticalProbabilitySARS-CoV-2Time Factors

Identifiers

PMID33414470
PMCPMC7788536
OpenAlexW3120274174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.