Evidence map›Paper›PMID 33414454›Full record

ReviewNature reviews. Disease primers2021

Tendinopathy.

Neal L Millar, Karin G Silbernagel, Kristian Thorborg, Paul D Kirwan, Leesa M Galatz, Geoffrey D Abrams, George A C Murrell, Iain B McInnes, Scott A Rodeo

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 362 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
362citing papers in PubMed, 10 pooled it
90.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05370092 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Percutaneous Needle Electrolysis on Tibialis Posterior Tendinopathy

TypeinterventionalSponsorUniversidad Rey Juan CarlosRan2022 to 2025Enrolled46ConditionsPosterior Tibial Tendon DysfunctionArmsPercutaneous needle electrolysis, Therapeutic exercise, Manual therapy
NCT07540806 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Ultrasound-Guided Percutaneous Needle Tenotomy (PNT) vs Percutaneous Ultrasonic Needle Tenotomy (PUT) for Gluteal Tendinosis

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2028Enrolled110ConditionsTendinopathy, Tendinosis, Gluteal TendinitisArmsPercutaneous needle tenotomy (PNT), Percutaneous ultrasonic tenotomy (PUT, Tenex Device)
3 · Its place in the literature

Who cites it

362 citing papers in PubMed, 10 syntheses or guidelines pooled it, 743 citations in OpenAlex.

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302 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Neal L MillarInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. neal.millar@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-9251-9907
Karin G SilbernagelDepartment of Physical Therapy, University of Delaware, Newark, DE, USA.
Kristian ThorborgInstitute of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
Paul D KirwanSchool of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland.
Leesa M GalatzDepartment of Orthopaedic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, NY, USA.
Geoffrey D AbramsDepartment of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
George A C MurrellOrthopaedic Research Institute, Sydney, Australia.
Iain B McInnesInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-4449-8501
Scott A RodeoHospital for Special Surgery, New York, NY, USA.ORCID http://orcid.org/0000-0002-0745-9880
Hospital for Special Surgery · USMount Sinai Health System · USRoyal College of Surgeons in Ireland · IEStanford University · USSydney Orthopaedic Research Institute · AUUniversity of Delaware · USUniversity of Glasgow · GBWellcome Centre for Molecular Parasitology · GB

Funding

Medical Research Council MR/R020515/1
6 · The paper itself

Abstract

Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.

Indexed as

Achilles TendonTendinopathyHumansRotator Cuff

Identifiers

PMID33414454
OpenAlexW4211130574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.