Evidence map›Paper›PMID 33414374›Full record

Trial reportBlood cancer journal2021

Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma.

Marc-Andrea Baertsch, Elias K Mai, Thomas Hielscher, Uta Bertsch, Hans J Salwender, Markus Munder, Stephan Fuhrmann, Ulrich Dührsen, Peter Brossart, Kai Neben and 23 more

Open access · goldAbstract readClinical Trial, Phase IIIMulticenter Study
In one paragraph

Trial report in Blood cancer journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Safety and Efficacy of Combination Maintenance Therapy with Ixazomib and Lenalidomide in Patients with Posttransplant Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 3 countries.

Marc-Andrea BaertschDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-4000-6904
Elias K MaiDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-6226-1252
Thomas HielscherDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Uta BertschDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Hans J SalwenderAsklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg, Germany.
Markus MunderDepartment of Internal Medicine III, University Medical Center Mainz, Mainz, Germany.
Stephan FuhrmannDepartment of Hematology and Stem Cell Transplantation, Helios Hospital Berlin Buch, Berlin, Germany.ORCID 0000-0002-7785-2565
Ulrich DührsenDepartment of Hematology, University Clinic Essen, Essen, Germany.
Peter BrossartUniversity Hospital Bonn, Bonn, Germany.
Kai NebenDepartment of Hematology and Oncology, Klinikum Baden Baden, Baden Baden, Germany.
Jana SchlenzkaDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Christina KunzDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marc S RaabDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Jens HillengaßDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Anna JauchInstitute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
Anja SeckingerDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Dirk HoseDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Steffen LuntzCoordination Centre for Clinical Trials (KKS) Heidelberg, Heidelberg, Germany.
Pieter SonneveldDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Henk LokhorstDepartment of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
Hans MartinDepartment of Medicine, Hematology/Oncology, Goethe-University of Frankfurt, Frankfurt, Germany.
Martin GoernerDepartment of Hematology, Oncology and Palliative Care, Klinikum Bielefeld, Bielefeld, Germany.
Martin HoffmannMedical Clinic A, Klinikum Ludwigshafen, Ludwigshafen, Germany.
Hans-Walter LindemannDepartment of Hematology and Oncology, Katholisches Krankenhaus Hagen, Hagen, Germany.
Helga BernhardInternal Medicine V, Klinikum Darmstadt, Darmstadt, Germany.
Igor W BlauMedical Clinic, Charité University Medicine Berlin, Berlin, Germany.
Christof ScheidDepartment of Internal Medicine I, University Hospital Köln, Köln, Germany.
Britta BesemerDepartment of Hematology, Oncology and Immunology, University Hospital Tübingen, Tübingen, Germany.
Katja C WeiselDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-9422-6614
Mathias HänelDepartment of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.
Jan DürigDepartment of Hematology, University Clinic Essen, Essen, Germany.
Hartmut GoldschmidtDepartment of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany. hartmut.goldschmidt@med.uni-heidelberg.de.ORCID 0000-0003-0961-0035
German-Speaking Myeloma Multicenter Group (GMMG)
Heidelberg University · DEEssen University Hospital · DEGerman Cancer Research Center · DEAmsterdam UMC Location Vrije Universiteit Amsterdam · NLAsklepios Klinik Altona · DECharité - Universitätsmedizin Berlin · DEErasmus MC Cancer Institute · NLGoethe University Frankfurt · DEHelios Hospital Berlin-Buch · DEJohannes Gutenberg University Mainz · DEKatholisches Krankenhaus St. Johann Nepomuk · DEKlinikum Bielefeld · DEKlinikum Chemnitz · DEKlinikum Darmstadt · DEKlinikum Ludwigshafen · DEKlinikum Mittelbaden · DERoswell Park Comprehensive Cancer Center · USUniversität Hamburg · DEUniversity Children's Hospital Tübingen · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents in clinical trials. We retrospectively compared bortezomib (BTZ; n = 138) or LEN (n = 183) MT from two subsequent GMMG phase III trials. All patients received three cycles of BTZ-based triplet induction and post-ASCT MT. BTZ MT (1.3 mg/m

Indexed as

Hematopoietic Stem Cell TransplantationAntineoplastic AgentsBortezomibFemaleHumansImmunologic FactorsLenalidomideMaintenance ChemotherapyMaleMiddle AgedMultiple MyelomaRetrospective StudiesTransplantation, AutologousAntineoplastic AgentsBortezomibImmunologic FactorsLenalidomide

Identifiers

PMID33414374
PMCPMC7791127
OpenAlexW3120452471

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.