ArticlePediatrics2021
Timing of Co-occurring Chronic Conditions in Children With Neurologic Impairment.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gastrostomy plus fundoplication or gastro-jejunal tube or gastrostomy alone for treating or preventing gastro-esophageal reflux in children and adolescents with neurological impairment.The Cochrane database of systematic reviews · 2026Pooled it
- Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.Developmental neuroscience · 2022Trial
- Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency.Journal of inherited metabolic disease · 2026Review
- Pediatric Neuropalliative Medicine Clinic: Five-Year Data Characterizing a Novel Model of Outpatient Care.Annals of the Child Neurology Society · 2026Article
- The Impact of Diet and Enteral Tube Type on Gastric Bile Acid Concentrations and Pulmonary Outcomes.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Article
- The evolution of nutrition management in children with severe neurological impairment with a focus on cerebral palsy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Review
- Pericapsular Nerve Group (PENG) Block for Pediatric Hip Surgery: A Report of Three Cases.Cureus · 2025Article
- Pediatric Intensive Care Provider Attitudes About Children with Medical Complexity and Neurologic Impairment: A Qualitative Study.Children (Basel, Switzerland) · 2024Article
- Intravenous antibiotics for urinary tract infections in children with neurologic impairment.Journal of hospital medicine · 2024Article
- Intravenous antibiotics for urinary tract infections in children with neurologic impairment.Journal of hospital medicine · 2024Article
- Predictive Modeling to Identify Children With Complex Health Needs At Risk for Hospitalization.Hospital pediatrics · 2023Article
- Pharmacogenetic profiling via genome sequencing in children with medical complexity.Pediatric research · 2023Article
- Making Polypharmacy Safer for Children with Medical Complexity.The Journal of pediatrics · 2023Article
- Anticholinergic Medications and Parent-Reported Anticholinergic Symptoms in Neurologically Impaired Children.Journal of pain and symptom management · 2023Article
- Impact of the COVID-19 pandemic on hospitalizations of children with neurologic impairment.Journal of hospital medicine · 2023Article
- Clinical characteristics of children with severe neurologic impairment: A scoping review.Journal of hospital medicine · 2023Article
- Healthcare Utilization for Medicaid-Insured Children with Medical Complexity: Differences by Sociodemographic Characteristics.Maternal and child health journal · 2022Article
- 5-year risk of "adult-onset" chronic diseases during childhood and adolescent transitioning for individuals with cerebral palsy.Preventive medicine reports · 2022Article
- Validation of Neurologic Impairment Diagnosis Codes as Signifying Documented Functional Impairment in Hospitalized Children.Academic pediatrics · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundChildren with neurologic impairment (NI) are at risk for developing co-occurring chronic conditions, increasing their medical complexity and morbidity. We assessed the prevalence and timing of onset for those conditions in children with NI.
methodsThis longitudinal analysis included 6229 children born in 2009 and continuously enrolled in Medicaid through 2015 with a diagnosis of NI by age 3 in the IBM Watson Medicaid MarketScan Database. NI was defined with an existing diagnostic code set encompassing neurologic, genetic, and metabolic conditions that result in substantial functional impairments requiring subspecialty medical care. The prevalence and timing of co-occurring chronic conditions was assessed with the Agency for Healthcare Research and Quality Chronic Condition Indicator system. Mean cumulative function was used to measure age trends in multimorbidity.
resultsThe most common type of NI was static (56.3%), with cerebral palsy (10.0%) being the most common NI diagnosis. Respiratory (86.5%) and digestive (49.4%) organ systems were most frequently affected by co-occurring chronic conditions. By ages 2, 4, and 6 years, the mean (95% confidence interval [CI]) numbers of co-occurring chronic conditions were 3.7 (95% CI 3.7-3.8), 4.6 (95% CI 4.5-4.7), and 5.1 (95% CI 5.1-5.2). An increasing percentage of children had ≥9 co-occurring chronic conditions as they aged: 5.3% by 2 years, 10.0% by 4 years, and 12.8% by 6 years.
conclusionsChildren with NI enrolled in Medicaid have substantial multimorbidity that develops early in life. Increased attention to the timing and types of multimorbidity in children with NI may help optimize their preventive care and case management health services.
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Registered trials
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