Evidence map›Paper›PMID 33414227›Full record

ArticleAJNR. American journal of neuroradiology2021

Regional and Volumetric Parameters for Diffusion-Weighted WHO Grade II and III Glioma Genotyping: A Method Comparison.

S C Thust, J A Maynard, M Benenati, S J Wastling, L Mancini, Z Jaunmuktane, S Brandner, H R Jäger

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Automated Diffusion Analysis for Noninvasive Prediction ofAJNR. American journal of neuroradiology · 2025
    Article
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  8. Prediction ofFrontiers in neurology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

S C ThustFrom the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK s.thust@ucl.ac.uk.ORCID 0000-0001-5136-6000
J A MaynardFrom the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK.ORCID 0000-0002-4089-7575
M BenenatiLysholm Department of Neuroradiology (S.C.T., J.A.M., M.B., S.J.W., L.M., H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK.ORCID 0000-0001-8976-5939
S J WastlingFrom the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK.ORCID 0000-0003-4648-9932
L ManciniFrom the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK.ORCID 0000-0002-4596-3551
Z JaunmuktaneDepartment of Clinical and Movement Neurosciences (Z.J.).ORCID 0000-0001-7738-8881
S BrandnerNeurodegenerative Disease (S.B.), UCL Queen Square Institute of Neurology, and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-9821-0342
H R JägerFrom the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK.ORCID 0000-0002-6403-4184
Institute of Ophthalmology · MXUniversity College Hospital · GBAgostino Gemelli University Polyclinic · ITCentre for Movement Disorders · CAUniversity College London Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeStudies consistently report lower ADC values in MATERIALS AND

methodsTreatment-naïve World Health Organization grade II and III gliomas were analyzed by 3 neuroradiologist readers blinded to tissue results. ADC minimum and mean ROIs were defined in tumor and in normal-appearing white matter to calculate normalized values. T2-weighted tumor VOIs were registered to ADC maps with histogram parameters (mean, 2nd and 5th percentiles) extracted. Nonparametric testing (eta

resultsThe study included 283 patients with 79

conclusionsRegional normalized mean ADC measurements are noninferior to volumetric segmentation for defining solid glioma

Indexed as

Genotyping TechniquesAdultAgedBrain NeoplasmsDiffusion Magnetic Resonance ImagingFemaleGenotypeGliomaHumansIsocitrate DehydrogenaseMaleMiddle AgedMutationRetrospective StudiesWorld Health OrganizationIsocitrate Dehydrogenase

Identifiers

PMID33414227
PMCPMC7959449
OpenAlexW3120630772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.