Evidence map›Paper›PMID 33414193›Full record

ReviewScience (New York, N.Y.)2021

Making sense of neural development by comparing wiring strategies for seeing and hearing.

A A Sitko, L V Goodrich

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Synaptic promiscuity in brain development.Current biology : CB · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

A A SitkoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7601-6143
L V GoodrichDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. lisa_goodrich@hms.harvard.edu.ORCID https://orcid.org/0000-0002-3331-8600

Funding

Genetic Dissection of Auditory Circuit AssemblyR01DC009223 · NIDCD · HARVARD MEDICAL SCHOOL · PI Lisa Goodrich · 2009 to 2026
$8.4M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2016 to 2020
$5.2M
Afferent-efferent interactions in the developing cochleaR01DC015974 · NIDCD · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2017 to 2021
$2.4M
Molecular control of neuronal shape and connectivity in the developing retinaR01EY024884 · NEI · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2016 to 2019
$1.7M
Generation of mouse models to define the structural basis of Ntn1-DCC activityR21NS113562 · NINDS · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2019 to 2019
$466k
NEI NIH HHS R01 EY024884NICHD NIH HHS U54 HD090255NIDCD NIH HHS R01 DC009223NIDCD NIH HHS R01 DC015974NINDS NIH HHS R21 NS113562
6 · The paper itself

Abstract

The ability to perceive and interact with the world depends on a diverse array of neural circuits specialized for carrying out specific computations. Each circuit is assembled using a relatively limited number of molecules and common developmental steps, from cell fate specification to activity-dependent synaptic refinement. Given this shared toolkit, how do individual circuits acquire their characteristic properties? We explore this question by comparing development of the circuitry for seeing and hearing, highlighting a few examples where differences in each system's sensory demands necessitate different developmental strategies.

Indexed as

NeurogenesisAnimalsAuditory PathwaysCochlear NucleusHearingMiceRetinaSensory Receptor CellsSynapsesVision, OcularVisual Pathways

Identifiers

PMID33414193
PMCPMC8034811

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.