Evidence map›Paper›PMID 33414189›Full record

ArticleScience (New York, N.Y.)2021

RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.

Seyed-Fakhreddin Torabi, Anand T Vaidya, Kazimierz T Tycowski, Suzanne J DeGregorio, Jimin Wang, Mei-Di Shu, Thomas A Steitz, Joan A Steitz

Open access · bronzeAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. RNA Triple Helices: From Structures and Mechanisms to Therapeutic Targets.International journal of biological sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Structure and function analysis of a type III preQThe Journal of biological chemistry · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Seyed-Fakhreddin TorabiDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.ORCID https://orcid.org/0000-0003-1643-3583
Anand T VaidyaDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.
Kazimierz T TycowskiDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.ORCID https://orcid.org/0000-0002-4212-8585
Suzanne J DeGregorioDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.
Jimin WangDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.
Mei-Di ShuDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.
Thomas A SteitzDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA.ORCID https://orcid.org/0000-0002-3357-3505
Joan A SteitzDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA. joan.steitz@yale.edu.ORCID https://orcid.org/0000-0002-0534-8722
Howard Hughes Medical Institute · USYale University · US

Funding

X-RAY ANALYSIS OF PROTEIN STRUCTURE AND FUNCTIONP01GM022778 · NIGMS · YALE UNIVERSITY · PI BREAKER, RONALD R · 1985 to 2019
$26.1M
VIRAL SMALL RNPS--ROLES IN CELL TRANSFORMATIONP01CA016038 · NCI · YALE UNIVERSITY · PI DIMAIO, DANIEL C. · 1985 to 2020
$25.6M
Viral Noncoding RNAs and Cell TransformationR01CA259386 · NCI · YALE UNIVERSITY · PI JOAN A. STEITZ · 2022 to 2026
$3.2M
Howard Hughes Medical InstituteNCI NIH HHS P01 CA016038NCI NIH HHS R01 CA259386NIGMS NIH HHS P01 GM022778
6 · The paper itself

Abstract

Polyadenylate [poly(A)] tail addition to the 3' end of a wide range of RNAs is a highly conserved modification that plays a central role in cellular RNA function. Elements for nuclear expression (ENEs) are cis-acting RNA elements that stabilize poly(A) tails by sequestering them in RNA triplex structures. A crystal structure of a double ENE from a rice hAT transposon messenger RNA complexed with poly(A)

Indexed as

PolyadenylationRNA StabilityCrystallizationNucleic Acid ConformationOryzaPoly ARNA, MessengerPoly ARNA, Messenger

Identifiers

PMID33414189
PMCPMC9491362
OpenAlexW3120890309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.