Evidence map›Paper›PMID 33414149›Full record

ArticleBMJ open2021

Cardiovascular and cerebrovascular health after pre-eclampsia: the Motherhealth prospective cohort study protocol.

Eliza C Miller, Andrea Miltiades, Nicole Pimentel-Soler, Whitney A Booker, Ruth Landau-Cahana, Randolph S Marshall, Mary E D'Alton, Ronald Wapner, Kirsten Lawrence Cleary, Natalie Bello

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eliza C MillerDepartment of Neurology, Columbia University, New York, New York, USA ecm2137@cumc.columbia.edu.ORCID 0000-0002-7108-8906
Andrea MiltiadesDepartment of Anesthesiology, Columbia University, New York, New York, USA.
Nicole Pimentel-SolerDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
Whitney A BookerDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
Ruth Landau-CahanaDepartment of Anesthesiology, Columbia University, New York, New York, USA.
Randolph S MarshallDepartment of Neurology, Columbia University, New York, New York, USA.
Mary E D'AltonDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
Ronald WapnerDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
Kirsten Lawrence ClearyDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
Natalie BelloDepartment of Medicine, Cardiology Division, Columbia University, New York, New York, USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Neurovascular Unit Dysfunction in Women with Severe PreeclampsiaK23NS107645 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, ELIZA C · 2019 to 2023
$1.1M
NCATS NIH HHS UL1 TR001873NINDS NIH HHS K23 NS107645
6 · The paper itself

Abstract

introductionCardiovascular and cerebrovascular diseases (CCVDs) are the leading cause of maternal mortality in the first year after delivery. Women whose pregnancies were complicated by pre-eclampsia are at particularly high risk for adverse events. In addition, women with a history of pre-eclampsia have higher risk of CCVD later in life. The physiological mechanisms that contribute to increased CCVD risk in these women are not well understood, and the optimal clinical pathways for postpartum CCVD risk reduction are not yet defined. METHODS AND ANALYSIS: The Motherhealth Study (MHS) is a prospective cohort study at Columbia University Irving Medical Center (CUIMC), a quaternary care academic medical centre serving a multiethnic population in New York City. MHS began recruitment on 28 September 2018 and will enrol 60 women diagnosed with pre-eclampsia with severe features in the antepartum or postpartum period, and 40 normotensive pregnant women as a comparison cohort. Clinical data, biospecimens and measures of vascular function will be collected from all participants at the time of enrolment. Women in the pre-eclampsia group will complete an additional three postpartum study visits over 12-24 months. Visits will include additional detailed cardiovascular and cerebrovascular phenotyping. As this is an exploratory, observational pilot study, only descriptive statistics are planned. Data will be used to inform power calculations for future planned interventional studies. ETHICS AND DISSEMINATION: The CUIMC Institutional Review Board approved this study prior to initiation of recruitment. All participants signed informed consent prior to enrolment. Results will be disseminated to the clinical and research community, along with the public, on completion of analyses. Data will be shared on reasonable request.

Indexed as

Pre-EclampsiaBlood PressureCohort StudiesFemaleHumansNew York CityObservational Studies as TopicPregnancyProspective Studieshypertensionmaternal medicinepreventive medicinestrokestroke medicinevascular medicine

Identifiers

PMID33414149
PMCPMC7797304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.