Evidence map›Paper›PMID 33414132›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

The State of Melanoma: Emergent Challenges and Opportunities.

Michael B Atkins, Clara Curiel-Lewandrowski, David E Fisher, Susan M Swetter, Hensin Tsao, Julio A Aguirre-Ghiso, Maria S Soengas, Ashani T Weeraratna, Keith T Flaherty, Meenhard Herlyn and 27 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 106 citations in OpenAlex.

  1. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With AdvancedJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Advances in Pathogenesis and Treatment of Skin Cancer.International journal of molecular sciences · 2025
    Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 2 countries.

Michael B AtkinsLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C. gmerlino@helix.nih.gov Mba41@georgetown.edu.
Clara Curiel-LewandrowskiDepartment of Dermatology, The University of Arizona Cancer Center Skin Cancer Institute, College of Medicine, University of Arizona, Tucson, Arizona.
David E FisherDepartment of Dermatology & Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Susan M SwetterDepartment of Dermatology, Pigmented Lesion & Melanoma Program, Stanford University Medical Center & Cancer Institute, VA Palo Alto Health Care System, Palo Alto, California.ORCID https://orcid.org/0000-0003-2098-2948
Hensin TsaoMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Julio A Aguirre-GhisoDivision of Hematology & Oncology, Departments of Medicine, Otolaryngology, & Oncological Sciences, Precision Immunology Institute, Black Family Stem Cell Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Maria S SoengasMolecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Ashani T WeeraratnaDepartment of Biochemistry & Molecular Biology, Johns Hopkins Bloomberg School of Public Health & Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Keith T FlahertyMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Meenhard HerlynThe Wistar Institute, Philadelphia, Pennsylvania.
Jeffrey A SosmanRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois.
Hussein A TawbiDivision of Cancer Medicine, Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Anna C PavlickWeill Cornell Medical College, New York, New York.ORCID https://orcid.org/0000-0001-7088-0742
Pamela B CassidyKnight Cancer Institute & Department of Dermatology, Oregon Health & Science University, Portland, Oregon.
Sunandana ChandraRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois.
Paul B ChapmanMemorial Sloan Kettering Cancer Center & Weill Cornell Medical College, New York, New York.
Adil DaudUniversity of California, San Francisco, California.ORCID https://orcid.org/0000-0002-6617-8421
Zeynep ErogluDepartment of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Laura K FerrisDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Bernard A FoxDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Laboratory of Molecular & Tumor Immunology, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, Oregon.
Jeffrey E GershenwaldDepartments of Surgical Oncology & Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Geoffrey T GibneyLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.
Douglas GrossmanHuntsman Cancer Institute & Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah.
Brent A HanksDivision of Medical Oncology, Department of Medicine, Department of Pharmacology & Cancer Biology, Center for Cancer Immunotherapy, Duke University Medical Center, Durham, North Carolina.ORCID https://orcid.org/0000-0002-2803-3272
Douglas HannifordDepartment of Pathology, NYU Grossman School of Medicine, Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York, New York.ORCID https://orcid.org/0000-0001-6790-8441
Eva HernandoDepartment of Pathology, NYU Grossman School of Medicine, Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York, New York.
Joanne M JeterHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.ORCID https://orcid.org/0000-0002-3570-4476
Douglas B JohnsonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Samir N KhleifThe Loop Laboratory for Immuno-Oncology Lombardi Cancer Center, Georgetown School of Medicine, Georgetown University, Washington, D.C.
John M KirkwoodUniversity of Pittsburgh, Pittsburgh, Pennsylvania.
Sancy A LeachmanKnight Cancer Institute & Department of Dermatology, Oregon Health & Science University, Portland, Oregon.
Darren MaysDepartment of Internal Medicine, College of Medicine, The Ohio State University, Center for Tobacco Research, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.
Kelly C NelsonDepartment of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID https://orcid.org/0000-0002-5042-7366
Vernon K SondakDepartment of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Ryan J SullivanMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Glenn Merlino
Melanoma Research Foundation
Massachusetts General Hospital · USGeorgetown University · USThe University of Texas MD Anderson Cancer Center · USEastern Cooperative Oncology Group · USHuntsman Cancer Institute · USMoffitt Cancer Center · USOregon Health & Science University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityUniversity of Pittsburgh · USCenter for Cancer Research · USCornell University · USDuke Medical Center · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USProvidence Portland Medical Center · USSpanish National Cancer Research Centre · ESThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Wistar Institute · USTisch Hospital · USUniversity of Arizona · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Targeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1M
Genetically Engineered Mouse Models to Study RTK Function in MelanomaZIABC008756 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MERLINO, GLENN T. · 2009 to 2024
$17.7M
Project 4P50CA225450 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIRCHHOFF, TOMAS · 2019 to 2025
$12.5M
Preclinical Mouse Models for Studying Immune Checkpoint Inhibitor ResponseZIABC011167 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MERLINO, GLENN T. · 2009 to 2024
$12.4M
The University of Texas MD Anderson Cancer Center SPORE in MelanomaP50CA221703 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAVIES, MICHAEL · 2019 to 2023
$10.3M
Sex Differences in Methylome Alterations and Mutational Burden in Early Stage MelanomaP01CA206980 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BERWICK, MARIANNE, THOMAS, NANCY E. · 2017 to 2022
$10.1M
A Diagnostic Microarray for hemorrhagic fever encephalitis virusesU01AI070374 · NIAID · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2006 to 2010
$3.9M
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skinR01CA232256 · NCI · WISTAR INSTITUTE · PI CUKIERMAN, EDNA, RAJ, ARJUN · 2019 to 2023
$3.0M
Intramural NIH HHS ZIA BC008756NCI NIH HHS P01 CA114046NCI NIH HHS P01 CA206980NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA221703NCI NIH HHS P50 CA225450NCI NIH HHS R01 CA232256NIAID NIH HHS U01 AI070374
6 · The paper itself

Abstract

Five years ago, the Melanoma Research Foundation (MRF) conducted an assessment of the challenges and opportunities facing the melanoma research community and patients with melanoma. Since then, remarkable progress has been made on both the basic and clinical research fronts. However, the incidence, recurrence, and death rates for melanoma remain unacceptably high and significant challenges remain. Hence, the MRF Scientific Advisory Council and Breakthrough Consortium, a group that includes clinicians and scientists, reconvened to facilitate intensive discussions on thematic areas essential to melanoma researchers and patients alike, prevention, detection, diagnosis, metastatic dormancy and progression, response and resistance to targeted and immune-based therapy, and the clinical consequences of COVID-19 for patients with melanoma and providers. These extensive discussions helped to crystalize our understanding of the challenges and opportunities facing the broader melanoma community today. In this report, we discuss the progress made since the last MRF assessment, comment on what remains to be overcome, and offer recommendations for the best path forward.

Indexed as

Practice Guidelines as TopicBiomedical ResearchCOVID-19HumansMedical OncologyMelanomaSARS-CoV-2Skin Neoplasms

Identifiers

PMID33414132
PMCPMC8127340
OpenAlexW3118853432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.