ArticleInternational psychogeriatrics2021
Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.
Article in International psychogeriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Network based statistics associates increased connectivity to REM sleep disorder and hallucinations in early DLB.NPJ Parkinson's disease · 2026Article
- Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer's diseases with cognitive decline.GeroScience · 2026Article
- Core Clinical Features Associated With Survival in Patients With Dementia With Lewy Bodies.Neurology · 2025Article
- Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy.Frontiers in neurology · 2025Article
- Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.AJNR. American journal of neuroradiology · 2023Article
- Cortical connectivity of cholinergic basal forebrain in Parkinson's disease with mild cognitive impairment.Quantitative imaging in medicine and surgery · 2023Article
- Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment.CNS neuroscience & therapeutics · 2023Article
- Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Temporal and Spatial Analysis of Alzheimer's Disease Based on an Improved Convolutional Neural Network and a Resting-State FMRI Brain Functional Network.International journal of environmental research and public health · 2022Article
- Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure.Frontiers in psychiatry · 2022Article
- Characterizing the long-term cognitive impairment following delirium episodes: A call to action.Aging medicine (Milton (N.S.W)) · 2021Article
- Occipital atrophy signature in prodromal Lewy bodies disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.
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