ReviewKnee surgery & related research2021
A systematic review comparing the results of early vs delayed ligament surgeries in single anterior cruciate ligament and multiligament knee injuries.
Review in Knee surgery & related research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Arthrofibrosis is a common but poorly defined complication in multiligament knee injuries: a systematic review.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Diagnosis, Treatment, and Current Controversies in Multiligament Knee Injuries: A Narrative Review.Cureus · 2026Review
- Outcomes Following Multiligament Knee Injuries: A Systematic Review of Studies With a Minimum 7-Year Follow-up.Orthopaedic journal of sports medicine · 2026Review
- One-Stage Versus Two-Stage ACL Reconstruction with Concomitant MCL Surgery in Combined ACL and MCL Injuries: A Minimum 2-Year Follow-Up Study.Journal of clinical medicine · 2026Article
- Rehabilitation alone after anterior cruciate ligament injury yields greater limb symmetry but lower knee related self-efficacy without limiting return to preinjury activity level.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Delayed Surgery and Adenosine, Lidocaine, and MgThe American journal of sports medicine · 2025Article
- Outcomes of acute versus delayed multi-ligament knee injury reconstruction: A retrospective analysis with mean 3.6-year follow-up.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- How do surgically treated multiligamentous knee injuries affect overall complication rate and especially stiffness? A systematic review.Knee surgery & related research · 2025Review
- A Systematic Review of all Published Systematic Reviews (SRs) on Multiligament Knee Injuries (MLKIs).Indian journal of orthopaedics · 2025Review
- Knee-Spanning External Fixation in the Management of Knee Dislocations and Multiligamentous Knee Injuries: A Narrative Review.Open access journal of sports medicine · 2025Review
- A Modern-Day Algorithm for the Treatment of Multi-Ligament Knee Injuries.Indian journal of orthopaedics · 2024Article
- Effect of Timing of Surgery on the Outcomes and Complications in Multi-ligament Knee Injuries: An Overview of Systematic Reviews and A Meta-analysis.Indian journal of orthopaedics · 2024Review
- Delaying anterior cruciate ligament reconstruction for more than 3 or 6 months results in lower risk of revision surgery.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024Article
- Surgical Management of Complex Multiligament Knee Injury: Case Report.Case reports in orthopedics · 2024Article
- Comparison of survival rates between total knee arthroplasty after a previous anterior cruciate ligament reconstruction and primary total knee arthroplasty via propensity score matching.Archives of orthopaedic and trauma surgery · 2023Article
- Clinical and MRI Outcomes of Repaired Peripheral Longitudinal Tears of the Posterior Horn of the Medial Meniscus With ACL Reconstruction: Results According to Tear Size.Orthopaedic journal of sports medicine · 2023Article
- Does a Lower Limb Balance Test after Anterior Cruciate Ligament Reconstruction Have a Significant Correlation with Postoperative Clinical Score, Stability, and Functional Performance Test?Clinics in orthopedic surgery · 2023Article
- Demographic characteristics of patients who underwent anterior cruciate ligament reconstruction at a tertiary care hospital in India.World journal of clinical cases · 2023Article
- Graft failure and revision rate after ACL repair with dynamic intraligamentary stabilization. One-year results of a prospective case series of 155 patients.Journal of experimental orthopaedics · 2023Article
- Outpatient-based diagnostic criteria for partial ACL injury: clinical outcomes of non-operative treatment and radiographic predictor.Archives of orthopaedic and trauma surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to compare clinical outcomes and incidence of concomitant injuries in patients undergoing early vs delayed surgical treatment of single anterior cruciate ligament (ACL) injury and multiligament knee injury (MLKI).
methodsA literature search using PubMed, Embase, the Cochrane Library, the Cumulative Index to Nursing and Allied Health, and Scopus from their inception to April 30, 2020 was conducted. Studies with levels I to IV evidence reporting the incidence of meniscus or cartilage injury according to early vs delayed surgery in single ACL injuries and MLKIs were included. In the meta-analysis, data based on the number of meniscus and cartilage injuries were extracted and pooled. Lysholm and Tegner scores were analyzed using two-sample Z-tests to calculate the non-weighted mean difference (NMD). A meta-regression analysis was also performed to determine the effect of single ACL injury and MLKI/study design.
resultsSixteen studies on single ACL injury and 14 studies on MLKI were included in this analysis. In the analysis, there were significant decreases in Lysholm score (NMD - 5.3 [95% confidence interval (CI) - 7.37 to - 3.23]) and Tegner score (NMD - 0.25 [95% CI - 0.45 to - 0.05]) and increases in risk of meniscus tear (odds ratio [OR] 1.73 [95% CI 1.1-2.73], p = 0.01) and cartilage injury (OR 2.48 [95% CI 1.46-4.2], p = 0.0007) in the delayed surgery group regardless of single ACL injury or MLKI. The result of the meta-regression analysis indicated that single ACL injury and MLKI/study design were not significant moderators of overall heterogeneity (p > 0.05).
conclusionsOur study suggests that delayed ACL surgery significantly resulted in a higher risk of meniscus tear and cartilage injury and decreased Lysholm and Tegner scores compared to early ACL surgery. The Lysholm scores in the delayed MLKI surgery group were significantly decreased, but the risks of meniscus tear and cartilage injury in the delayed MLKI surgery group remained unclear. LEVEL OF EVIDENCE: Level III, meta-analysis.
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