ArticleGenome medicine2021
An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets.
Article in Genome medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Harnessing AI for advancing pathogenic microbiology: a bibliometric and topic modeling approach.Frontiers in microbiology · 2024Pooled it
- Review
- Systematic analysis of SARS-CoV-2 Omicron subvariants' impact on B and T cell epitopes.PloS one · 2024Article
- The Spike Mutants Website: A Worldwide Used Resource against SARS-CoV-2.International journal of molecular sciences · 2022Article
- COVID-profiler: a webserver for the analysis of SARS-CoV-2 sequencing data.BMC bioinformatics · 2022Article
- Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2.Structural chemistry · 2022Article
- Lentil lectin derived fromEmerging microbes & infections · 2021Article
- Fusion of intelligent learning for COVID-19: A state-of-the-art review and analysis on real medical data.Neurocomputing · 2021Article
- Theoretical and experimental study of interaction of macroheterocyclic compounds with ORF3a of SARS-CoV-2.Scientific reports · 2021Article
- EpiSurf: metadata-driven search server for analyzing amino acid changes within epitopes of SARS-CoV-2 and other viral species.Database : the journal of biological databases and curation · 2021Article
- Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development-A Perspective Review.Vaccines · 2021Review
- Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.Nature structural & molecular biology · 2021Article
- Machine learning research towards combating COVID-19: Virus detection, spread prevention, and medical assistance.Journal of biomedical informatics · 2021Article
- Identification of Highly Conserved SARS-CoV-2 Antigenic Epitopes with Wide Coverage Using Reverse Vaccinology Approach.Viruses · 2021Article
- Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.bioRxiv : the preprint server for biology · 2021Article
- A systematic review on AI/ML approaches against COVID-19 outbreak.Complex & intelligent systems · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: http://genomics.lshtm.ac.uk/immuno (online); https://github.com/dan-ward-bio/COVID-immunoanalytics (source code).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.