ArticleClinical epigenetics2021
Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility.
Article in Clinical epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Oxidative Stress, Sperm DNA Fragmentation, or Both? Optimizing Test Selection in Male Infertility Evaluation.Antioxidants (Basel, Switzerland) · 2026Review
- Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm.Epigenetics · 2025Article
- Sperm DNA methylation profiling in patients with Kallmann syndrome.Endocrine connections · 2025Article
- Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration.Epigenetics · 2024Article
- Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine.Chemical reviews · 2024Review
- Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort.Molecular psychiatry · 2024Article
- Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine.Environmental epigenetics · 2024Article
- Intercontinental insights into autism spectrum disorder: a synthesis of environmental influences and DNA methylation.Environmental epigenetics · 2024Review
- Pre-autism: What a paediatrician should know about early diagnosis of autism.World journal of clinical pediatrics · 2023Review
- Investigating the impact of paternal aging on murine sperm miRNA profiles and their potential link to autism spectrum disorder.Scientific reports · 2023Article
- Epigenome-wide association study of systemic effects of obesity susceptibility in human twins.Epigenetics · 2023Article
- Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice.Genes & nutrition · 2023Article
- Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques.Fertility and sterility · 2023Article
- Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023Review
- Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder.Molecular psychiatry · 2023Review
- Cannabis and Paternal Epigenetic Inheritance.International journal of environmental research and public health · 2023Review
- Article
- Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies.Toxics · 2023Review
- Role of epigenetics in the etiology of hypospadias through penile foreskin DNA methylation alterations.Scientific reports · 2023Article
- Differentially methylated regions identified in bovine embryos are not observed in adulthood.Animal reproduction · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of ASD etiology, environmental epigenetics is now also thought to be an important factor. Epigenetic alterations, such as DNA methylation, have been correlated with ASD. The current study was designed to identify a DNA methylation signature in sperm as a potential biomarker to identify paternal offspring autism susceptibility. METHODS AND
resultsSperm samples were obtained from fathers that have children with or without autism, and the sperm then assessed for alterations in DNA methylation. A genome-wide analysis (> 90%) for differential DNA methylation regions (DMRs) was used to identify DMRs in the sperm of fathers (n = 13) with autistic children in comparison with those (n = 13) without ASD children. The 805 DMR genomic features such as chromosomal location, CpG density and length of the DMRs were characterized. Genes associated with the DMRs were identified and found to be linked to previously known ASD genes, as well as other neurobiology-related genes. The potential sperm DMR biomarkers/diagnostic was validated with blinded test sets (n = 8-10) of individuals with an approximately 90% accuracy.
conclusionsObservations demonstrate a highly significant set of 805 DMRs in sperm that can potentially act as a biomarker for paternal offspring autism susceptibility. Ancestral or early-life paternal exposures that alter germline epigenetics are anticipated to be a molecular component of ASD etiology.
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