Evidence map›Paper›PMID 33413534›Full record

ArticleJournal of orthopaedic surgery and research2021

Are vitamin D and vitamin D receptor levels different in children with developmental dysplasia of the hip?

Duran Topak, Muhammet Seyithanoğlu, Fatih Doğar, Ali Aydın Karadeniz, Burak Tanrıverdi, Fırat Ozan, Ökkeş Bilal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Duran TopakFaculty of Medicine, Department of Orthopaedic and Traumatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. drdtopak@gmail.com.ORCID https://orcid.org/0000-0002-1442-3392
Muhammet SeyithanoğluFaculty of Medicine, Department of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0002-8027-7549
Fatih DoğarFaculty of Medicine, Department of Orthopaedic and Traumatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0003-3848-1017
Ali Aydın KaradenizFaculty of Medicine, Department of Orthopaedic and Traumatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0003-3631-9825
Burak TanrıverdiFaculty of Medicine, Department of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0003-3993-3345
Fırat OzanDepartment of Orthopedics and Traumatology, Kayseri Training and Research Hospital, Kayseri, Turkey.ORCID https://orcid.org/0000-0002-2417-8343
Ökkeş BilalFaculty of Medicine, Department of Orthopaedic and Traumatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0002-7949-5434
Kahramanmaraş Sütçü İmam University · TRKayseri Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDevelopmental dysplasia of the hip (DDH) is a common disorder and associated with significant morbidity of the hip joint. Several risk factors have been identified for DDH. The aim of this study is to investigate whether vitamin D and vitamin D receptor (VDR) levels differ in children with DDH and whether they have an effect on DDH development. MATERIALS AND

methodsA total of 40 (17 males, 23 females; 9 right hips, 16 left hips, 15 bilateral hips) children who were treated for developmental dysplasia and 40 (23 males, 17 females) healthy children without any musculoskeletal system and metabolic disorders were included in this study between January and June 2019. Blood samples from the DDH and control groups of children were collected to measure the serum levels of vitamin D, VDR, calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP). The levels of Ca, P, and ALP were analyzed using the automated standard spectrophotometric laboratory method. The levels of vitamin D and VDR in the samples were analyzed using enzyme-linked immunoassay.

resultsThere were no significant differences in the serum levels of Ca, P, ALP, and vitamin D between the DDH and healthy groups (Ca 9.96 ± 0.47 vs. 9.92 ± 0.48 mg/dL, respectively, p = 0.721; P 5.3 ± 0.94 vs. 4.82 ± 0.88 mg/dL, respectively, p = 0.23; ALP 252.22 ± 170.15 vs. 245.3 ± 130.93 U/L, respectively, p = 0.839). However, serum VDR levels were significantly lower in children in the DDH group (5.77 ± 3.51 ng/mL) than in the healthy control group (9.25 ± 6.43 ng/mL) (p = 0.004).

conclusionsIn conclusion, we believe that low VDR levels can affect DDH regardless of the serum levels of Ca, P, ALP, and vitamin D. More comprehensive studies involving parents are needed to understand whether VDR levels mediate genetic transmission in DDH or not.

Indexed as

ChildChild, PreschoolDevelopmental Dysplasia of the HipFemaleHumansInfantMaleReceptors, CalcitriolVitamin DReceptors, CalcitriolVDR protein, humanVitamin DDevelopmental dysplasia of the hipRisk factorVitamin DVitamin D receptor

Identifiers

PMID33413534
PMCPMC7791744
OpenAlexW3120491323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.