Evidence map›Paper›PMID 33413530›Full record

ArticleInfectious agents and cancer2021

Association between oncogenic human papillomavirus type 16 and Killian polyp.

Lucia Oton-Gonzalez, John Charles Rotondo, Luca Cerritelli, Nicola Malagutti, Carmen Lanzillotti, Ilaria Bononi, Andrea Ciorba, Chiara Bianchini, Chiara Mazziotta, Monica De Mattei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. International journal of molecular sciences · 2022
    Article
  4. Review
  5. Review
  6. Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Lucia Oton-GonzalezDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
John Charles RotondoDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
Luca CerritelliDepartment of Biomedical Sciences and Specialistic Surgeries, ENT Section, University of Ferrara and University Hospital of Ferrara, 8, Aldo Moro Square, 44124, Cona, Italy.
Nicola MalaguttiDepartment of Biomedical Sciences and Specialistic Surgeries, ENT Section, University of Ferrara and University Hospital of Ferrara, 8, Aldo Moro Square, 44124, Cona, Italy.
Carmen LanzillottiDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
Ilaria BononiDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
Andrea CiorbaDepartment of Biomedical Sciences and Specialistic Surgeries, ENT Section, University of Ferrara and University Hospital of Ferrara, 8, Aldo Moro Square, 44124, Cona, Italy.
Chiara BianchiniDepartment of Biomedical Sciences and Specialistic Surgeries, ENT Section, University of Ferrara and University Hospital of Ferrara, 8, Aldo Moro Square, 44124, Cona, Italy.
Chiara MazziottaDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
Monica De MatteiDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy.
Stefano PelucchiDepartment of Biomedical Sciences and Specialistic Surgeries, ENT Section, University of Ferrara and University Hospital of Ferrara, 8, Aldo Moro Square, 44124, Cona, Italy.
Mauro TognonDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy. tgm@unife.it.
Fernanda MartiniDepartment of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics, School of Medicine, University of Ferrara, 64/B, Fossato di Mortara Street, 44121, Ferrara, Italy. mrf@unife.it.
University of Ferrara · IT

Funding

Fondazione Italiana per la Ricerca sul Cancro IG 21617
6 · The paper itself

Abstract

backgroundKillian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP.

methodsDNA from antral (n = 14) and nasal (n = 14) KP fractions were analyzed for HPV and HPyV sequences, genotypes, viral DNA load and physical status along with expression of viral proteins and p16 cellular protein.

resultsThe oncogenic HPV16 was detected in 3/14 (21.4%) antral KPs, whilst nasal KPs tested HPV-negative (0/14). The mean HPV16 DNA load was 4.65 ± 2.64 copy/10

conclusionsA fraction of KP tested positive for the oncogenic HPV16. HPV16 detection in the KP antral portion may be consistent with HPV16 infection derived from the maxillary sinus. HPV16 DNA integration represents a novel finding. Altogether, these data improve our knowledge on the association between KP and HPV infection, whereas it indicates that the KP onset is heterogeneous.

Indexed as

Human papillomavirusInfectionKillian polypNasal polypsPolyomavirus

Identifiers

PMID33413530
PMCPMC7792173
OpenAlexW3120322167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.