Evidence map›Paper›PMID 33413458›Full record

ArticleBiomedical engineering online2021

Proton density fat fraction of the spinal column: an MRI cadaver study.

Merle S Losch, Akash Swamy, Adrian Elmi-Terander, Erik Edström, Benno H W Hendriks, Jenny Dankelman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Merle S LoschDepartment of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. m.s.losch@tudelft.nl.ORCID http://orcid.org/0000-0001-9094-1266
Akash SwamyDepartment of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands.
Adrian Elmi-TeranderDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Erik EdströmDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Benno H W HendriksDepartment of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands.
Jenny DankelmanDepartment of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands.
Delft University of Technology · NLKarolinska University Hospital · SEPhilips (Netherlands) · NL

Funding

NWO-TTW 17553
6 · The paper itself

Abstract

backgroundThe increased popularity of minimally invasive spinal surgery calls for a revision of guidance techniques to prevent injuries of nearby neural and vascular structures. Lipid content has previously been proposed as a distinguishing criterion for different bone tissues to provide guidance along the interface of cancellous and cortical bone. This study aims to investigate how fat is distributed throughout the spinal column to confirm or refute the suitability of lipid content for guidance purposes.

resultsProton density fat fraction (PDFF) was assessed over all vertebral levels for six human cadavers between 53 and 92 years of age, based on fat and water MR images. According to their distance to the vertebra contour, the data points were grouped in five regions of interest (ROIs): cortical bone (-1 mm to 0 mm), pre-cortical zone (PCZ) 1-3 (0-1 mm; 1-2 mm; 2-3 mm), and cancellous bone ([Formula: see text] 3 mm). For PCZ1 vs. PCZ2, a significant difference in mean PDFF of between -7.59 pp and -4.39 pp on average was found. For cortical bone vs. PCZ1, a significant difference in mean PDFF of between -27.09 pp and -18.96 pp on average was found.

conclusionA relationship between distance from the cortical bone boundary and lipid content could be established, paving the way for guidance techniques based on fat fraction detection for spinal surgery.

Indexed as

CadaverMagnetic Resonance ImagingProtonsSpineAdipose TissueAgedAged, 80 and overFemaleHumansMaleMiddle AgedProtonsBone detectionLipid contentMagnetic resonance imagingMinimally invasive spine surgeryScrew placement

Identifiers

PMID33413458
PMCPMC7792224
OpenAlexW3119467998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.