Evidence map›Paper›PMID 33413421›Full record

ReviewJournal of nanobiotechnology2021

Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy.

Sean Swetledge, Jangwook P Jung, Renee Carter, Cristina Sabliov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 84 citations in OpenAlex.

  1. Potential of Nanoparticle-Based Phototherapies for Future Treatment of Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sean SwetledgeDepartment of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Jangwook P JungDepartment of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Renee CarterVeterinary Clinical Sciences, Louisiana State University and LSU Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA, 70803, USA.
Cristina SabliovDepartment of Biological and Agricultural Engineering, Louisiana State University and LSU Agricultural Center, Baton Rouge, LA, 70803, USA. csabliov@agcenter.lsu.edu.ORCID http://orcid.org/0000-0002-6992-8304
Louisiana State University · USLouisiana State University Agricultural Center · US

Funding

Directorate for Engineering OIA 1632854National Institute of Food and Agriculture 2018-07406U.S. Department of Agriculture 1008750
6 · The paper itself

Abstract

Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. This review seeks to discuss the available literature on the biodistribution of polymeric nanoparticles and discuss the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, with potential impact on clinical applications.

Indexed as

AnimalsBiological AvailabilityDelayed-Action PreparationsDrug Delivery SystemsEyeEye DiseasesHumansInflammationNanoparticlesPolymersRetinaTissue DistributionDelayed-Action PreparationsPolymersDrug delivery systemOcular biodistributionOcular drug deliveryPolymeric nanoparticle

Identifiers

PMID33413421
PMCPMC7789499
OpenAlexW3120426519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.