SynthesisBMC oral health2021
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Do systematic reviews of non- and micro-invasive treatment for caries lesions in children and adolescents adhere to the PRISMA reporting guidelines? A meta-research.Evidence-based dentistry · 2026Pooled it
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Resin Infiltration in the Conservative Management of Incipient Dental Caries: An Evidence-Based Review.Journal of clinical medicine · 2026Review
- Evaluation of Near-Infrared Transparent Sealants for Occlusal Sealing: An In Vitro Study.Materials (Basel, Switzerland) · 2025Article
- Effect of minimal intervention on carious lesions in primary teeth. An Umbrella review.Frontiers in dental medicine · 2025Review
- Long-Term Outcomes of Conservative versus Surgical Management of Dental Caries.Journal of pharmacy & bioallied sciences · 2024Article
- Equivalence study of the resin-dentine interface of internal tunnel restorations when using an enamel infiltrant resin with ethanol-wet dentine bonding.Scientific reports · 2024Article
- Resin infiltrant with antibacterial activity: effects of incorporation of DMAHDM monomer and NACP on physical and antimicrobial properties.Journal of applied oral science : revista FOB · 2024Article
- Introducing an Innovative Approach for Managing Proximal Non-Cavitated Carious Lesions in Juvenile Permanent Dentition: Combining Orthodontic Separators and Silver Fluoride Application.Medicina (Kaunas, Lithuania) · 2023Article
- Resin Infiltration of Non-Cavitated Proximal Caries Lesions in Primary and Permanent Teeth: A Systematic Review and Scenario Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2023Review
- Dental Caries and Its Management.International journal of dentistry · 2023Review
- A concise review of dental sealants in caries management.Frontiers in oral health · 2023Review
- Detecting Proximal Caries on Periapical Radiographs Using Convolutional Neural Networks with Different Training Strategies on Small Datasets.Diagnostics (Basel, Switzerland) · 2022Article
- Minimally Invasive Therapies for the Management of Dental Caries-A Literature Review.Dentistry journal · 2021Review
- Assessment of the Potential Ability to Penetrate into the Hard Tissues of the Root of an Experimental Preparation with the Characteristics of a Dental Infiltratant, Enriched with an Antimicrobial Component-Preliminary Study.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfiltration and sealing are micro-invasive treatments for arresting proximal non-cavitated caries lesions; however, their efficacies under different conditions remain unknown. This systematic review and meta-analysis aimed to evaluate the caries-arresting effectiveness of infiltration and sealing and to further analyse their efficacies across different dentition types and caries risk levels.
methodsSix electronic databases were searched for published literature, and references were manually searched. Split-mouth randomised controlled trials (RCTs) to compare the effectiveness between infiltration/sealing and non-invasive treatments in proximal lesions were included. The primary outcome was obtained from radiographical readings.
resultsIn total, 1033 citations were identified, and 17 RCTs (22 articles) were included. Infiltration and sealing reduced the odds of lesion progression (infiltration vs. non-invasive: OR = 0.21, 95% CI 0.15-0.30; sealing vs. placebo: OR = 0.27, 95% CI 0.18-0.42). For both the primary and permanent dentitions, infiltration and sealing were more effective than non-invasive treatments (primary dentition: OR = 0.30, 95% CI 0.20-0.45; permanent dentition: OR = 0.20, 95% CI 0.14-0.28). The overall effects of infiltration and sealing were significantly different from the control effects based on different caries risk levels (OR = 0.20, 95% CI 0.14-0.28). Except for caries risk at moderate levels (moderate risk: OR = 0.32, 95% CI 0.01-8.27), there were significant differences between micro-invasive and non-invasive treatments (low risk: OR = 0.24, 95% CI 0.08-0.72; low to moderate risk: OR = 0.38, 95% CI 0.18-0.81; moderate to high risk: OR = 0.17, 95% CI 0.10-0.29; and high risk: OR = 0.14, 95% CI 0.07-0.28). Except for caries risk at moderate levels (moderate risk: OR = 0.32, 95% CI 0.01-8.27), infiltration was superior (low risk: OR = 0.24, 95% CI 0.08-0.72; low to moderate risk: OR = 0.38, 95% CI 0.18-0.81; moderate to high risk: OR = 0.20, 95% CI 0.10-0.39; and high risk: OR = 0.14, 95% CI 0.05-0.37).
conclusionInfiltration and sealing were more efficacious than non-invasive treatments for halting non-cavitated proximal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.