ArticleBMC pregnancy and childbirth2021
Obstetric and neonatal outcomes in women with pregnancy associated cancer: a population-based study in Lombardy, Northern Italy.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Subsequent pregnancies after a diagnosis of pregnancy-associated cancer.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Leukemia during pregnancy and survivorship: gestational age-stratified multidisciplinary management framework.Clinical and experimental medicine · 2026Review
- Cancer and Pregnancy: Update of Estimates in Italy by Linking Data from Cancer Registries and Hospital Discharge Records.Cancers · 2025Article
- Review
- Evaluating Offspring After Pregnancy-Associated Cancer: A Systematic Review of Neonatal Outcomes.Cancers · 2025Review
- Cancer Diagnosis During Pregnancy and Livebirth Outcomes in the Adolescent and Young Adult Horizon Study.Journal of women's health (2002) · 2025Observational
- Laparotomy versus laparoscopy for the treatment of adnexal torsion during pregnancy.BMC pregnancy and childbirth · 2024Article
- Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024Review
- Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973-2017: A population-based matched study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Transient hypothyroidism in a neonate following maternal exposure to vinblastine during pregnancy: a case report and review.Frontiers in pediatrics · 2024Article
- Adverse birth outcomes of adolescent and young adult women diagnosed with cancer during pregnancy.Journal of the National Cancer Institute · 2023Article
- Breast Carcinogenesis during Pregnancy: Molecular Mechanisms, Maternal and Fetal Adverse Outcomes.Biology · 2023Review
- Pregnancy associated cancer, timing of birth and clinical decision making-a NSW data linkage study.BMC pregnancy and childbirth · 2023Observational
- Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.Birth (Berkeley, Calif.) · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
backgroundPregnancy associated cancer (PAC) may lead to adverse obstetric and neonatal outcomes. This study aims to assess the association between PACs and adverse perinatal outcomes [i.e. labor induction, iatrogenic delivery, preterm birth, small for gestational age (SGA) newborn, low Apgar score, major malformations, perinatal mortality] in Lombardy, Northern Italy.
methodsThis population-based historic cohort study used the certificate of delivery assistance and the regional healthcare utilization databases of Lombardy Region to identify beneficiaries of National Health Service who delivered between 2008 and 2017. PACs were defined through oncological ICD-9-CM codes reported in the hospital discharge forms. Each woman with PAC was matched to four women randomly selected from those cancer-free (1:4). Log-binomial regression models were fitted to estimate crude and adjusted prevalence ratio (aPR) and the corresponding 95% confidence interval (CI) of each perinatal outcome among PAC and cancer-free women.
resultsOut of the 657,968 deliveries, 831 PACs were identified (1.26 per 1000). PAC diagnosed during pregnancy was positively associated with labor induction or planned delivery (aPR=1.80, 95% CI: 1.57-2.07), cesarean section (aPR=1.78, 95% CI: 1.49-2.11) and premature birth (aPR=6.34, 95% CI: 4.59-8.75). No association with obstetric outcomes was found among PAC diagnosed in the post-pregnancy. No association of PAC, neither during pregnancy nor in post-pregnancy was found for SGA (aPR=0.71, 95% CI: 0.36-1.35 and aPR=1.04, 95% CI: 0.78-1.39, respectively), but newborn among PAC women had a lower birth weight (p-value< 0.001). Newborns of women with PAC diagnosed during pregnancy had a higher risk of borderline significance of a low Apgar score (aPR=2.65, 95% CI: 0.96-7.33) as compared to cancer-free women.
conclusionPAC, especially when diagnosed during pregnancy, is associated with iatrogenic preterm delivery, compromising some neonatal heath indicators.
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