Evidence map›Paper›PMID 33413200›Full record

ArticleBMC psychiatry2021

Analysis of the status of drug treatment in 746 inpatients with early-onset schizophrenia in China: a retrospective study.

Jiuping Zhang, Xin Cheng, Huihui Zhang, Ping Xu, Peiying Jin, Xiaoyan Ke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiuping ZhangThe Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, GuangZhou Road 264#, Nanjing, 210029, China.
Xin ChengThe Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, GuangZhou Road 264#, Nanjing, 210029, China.
Huihui ZhangThe Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, GuangZhou Road 264#, Nanjing, 210029, China.
Ping XuDepartment of Psychiatry, Nanjing Lishui Psychiatric Hospital, Nanjing, China.
Peiying JinThe Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, GuangZhou Road 264#, Nanjing, 210029, China.
Xiaoyan KeThe Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, GuangZhou Road 264#, Nanjing, 210029, China. kexiaoyan@njmu.edu.cn.
Nanjing Medical University · CNNanjing Brain Hospital · CN

Funding

the Key medical talents project of Jiangsu Province ZDRCA2016076the Major National Research and Development Program of China 2016YFC1306105
6 · The paper itself

Abstract

backgroundThere is limited evidence on the use of antipsychotics in patients with early-onset schizophrenia, which lags significantly behind the studies on adult patients' medication and has a large disparity from actual clinical needs. Hence, this study aims to analyse the status of the drug use and its changes for patients with early-onset schizophrenia in our ward and to provide references on clinical medications for children and adolescents with schizophrenia.

methodsThe distribution of antipsychotics on the day of discharge and their changes over time were retrospectively analysed in our inpatient department from March 2012 to July 2019. Descriptive statistical methods and χ2 tests were carried out.

resultsA total of 746 inpatients with early-onset schizophrenia were included. Among them, 99.3% of patients were prescribed atypical antipsychotic drugs, with 5.5% of patients prescribed typical antipsychotic drugs. The top five most commonly used antipsychotics were aripiprazole, olanzapine, risperidone, paliperidone and clozapine. Olanzapine and risperidone were used more frequently in men (P < 0.01), whereas aripiprazole was used less frequently (P < 0.01). Olanzapine and paliperidone were used more frequently in patients with adolescent-onset schizophrenia (AOS) (P < 0.05), and risperidone was used more frequently in patients with child-onset schizophrenia (COS) (P < 0.01). Multiple antipsychotics during hospitalization were prescribed in 23.1% of patients. The combination of aripiprazole and olanzapine was the most common in the AOS group, and the combination of risperidone and clozapine was the most common in the COS group. Before and after approval by the competent Chinese authorities, the use of paliperidone and aripiprazole tended to be stable.

conclusionAtypical antipsychotics have been increasingly valued and used clinically. The consideration of medications for patients with early-onset schizophrenia needs to include factors such as age, sex, and severity of illness, metabolism and cognitive function at baseline.

Indexed as

Antipsychotic AgentsPharmaceutical PreparationsSchizophreniaAdolescentAdultBenzodiazepinesChildChinaHumansInpatientsMaleRetrospective StudiesAntipsychotic AgentsBenzodiazepinesPharmaceutical PreparationsChildren and adolescentsDrugsSchizophreniaStatus of treatment

Identifiers

PMID33413200
PMCPMC7791722
OpenAlexW3119216916

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.