ArticleBMC geriatrics2021
The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study.
Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of an oral exercise intervention on pre-frailty or frailty in older people: a randomized clinical trial.Communications medicine · 2026Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- Article
- Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank.Biogerontology · 2025Article
- Depressive symptoms and frailty, effects of social distancing and isolation in older adults.Investigacion y educacion en enfermeria · 2025Article
- Frailty and associated risk factors in patients with Sjögren's disease: a cross-sectional study.Frontiers in immunology · 2025Article
- The impact of frailty on the use of social services, medication and mortality risk: a cross-sectional study.BMC geriatrics · 2024Article
- Association of HDL and LDL levels with osteoporosis in rheumatoid arthritis: a retrospective cohort study.European journal of medical research · 2024Article
- The association of adherence to 24-hour movement guidelines with frailty and mortality: cross-sectional and longitudinal analyses of NHANES data.Journal of activity, sedentary and sleep behaviors · 2024Article
- Activity diversity is associated with the prevention of frailty in community-dwelling older adults: The Otassha Study.Frontiers in public health · 2023Article
- Prevalence of frailty in patients with polymyalgia rheumatica and association with health-related quality of life, cognition and sarcopenia.Rheumatology (Oxford, England) · 2022Article
- Oral Factors as Predictors of Frailty in Community-Dwelling Older People: A Prospective Cohort Study.International journal of environmental research and public health · 2022Article
- Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUnderstanding potentially modifiable factors that influence the risk of frailty is a key concern for the management of this urgent contemporary public health challenge. This study evaluates the association between the use of various medications or alcohol and the incidence of frailty among older adults.
methodsThis study was a retrospective cohort study on older adults (≥ 65 years) using data from the longitudinal Survey of Health, Ageing and Retirement in Europe (SHARE survey, 28 countries). Medication use was measured as taking several different groups of medications. Alcohol use was assessed with SHARE questions corresponding to AUDIT-C. The outcome measure was the incidence of frailty after two years, defined by frailty index (FI) and frailty phenotype (FP). A multiple logistic regression model was used to evaluate the association with adjustment for several potential confounding factors.
resultsOf the 14,665 FI-population participants, 1800 (12.3%) developed frailty within two years. Of the 8133 FP-population participants, 2798 (34.4%) developed pre-frailty and 247 (3.0%) developed frailty within two years of baseline. After adjustment for potential confounding variables, non-hazardous alcohol use (adjusted OR; 95% CI for the FI-population: 0.68; 0.60-0.77) and hazardous alcohol use (0.80; 0.68-0.93) are associated with lower incidence of frailty compared to no alcohol use. The odds of frailty are increased when taking medications; the largest effect size was observed in older adults taking medication for chronic bronchitis (adjusted OR; 95% CI for the FI-population: 2.45; 1.87-3.22), joint pain and other pain medication (2.26; 2.00-2.54), medication for coronary and other heart disease (1.72; 1.52-1.96), medication for diabetes (1.69; 1.46-1.96), and medication for anxiety, depression and sleep problems (1.56; 1.33-1.84). Additionally, the risk of frailty was increased with stroke, Parkinson's disease and dementia.
conclusionsTaking certain groups of medication was associated with increased incidence of frailty and pre-frailty, which might be due to either medication use or the underlying disease. Alcohol use was associated with a lower risk of pre-frailty and frailty compared to no alcohol use, which might be due to reverse causality or residual confounding. There was no significant interaction effect between medication groups and alcohol use on frailty incidence.
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