ArticleBMC geriatrics2021
Burden of bloodstream infection in older persons: a population-based study.
Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Real-world use of novel β-lactams in immunologically vulnerable patients: insights from an Italian retrospective cohort.JAC-antimicrobial resistance · 2026Article
- A 5-Year Population-Based Study of Polymicrobial Enterococcal Bloodstream Infection in Southeast Minnesota.Mayo Clinic proceedings · 2026Article
- Predicting Gram-negative bloodstream infection in elderly patients after isolation of GNB from non-blood specimens: a machine learning-based tool.Frontiers in medicine · 2026Article
- Neutrophil-Percentage-to-Albumin Ratio and Monocyte-to-Albumin Ratio: Utility of the Combined Biomarkers in the Prediction of 30-Day Mortality in Male Diabetes Patients Over 80 Years Old with Bloodstream Infections.Clinical interventions in aging · 2026Article
- Distribution and Antibiotic Resistance of Pathogens in Bloodstream Infections Among Elderly Patients in Sichuan Province (2020-2024).Infection and drug resistance · 2026Article
- The relationship between catheter-related bloodstream infection and multi-drug resistant bacteria: a five-year retrospective study.BMC infectious diseases · 2025Article
- Incidence and resistance rates of Pseudomonas aeruginosa bloodstream infections in Switzerland: a nationwide surveillance study (2010-2022).Infection · 2025Observational
- Clinical features and risk factors of older adults with bloodstream infection.BMC geriatrics · 2025Article
- Machine learning model to predict sepsis in ICU patients with intracerebral hemorrhage.Scientific reports · 2025Article
- Research and predictive analysis of the disease burden of bloodstream infectious diseases in China.BMC infectious diseases · 2025Article
- Antimicrobial susceptibility of gram-negative strains isolated from bloodstream infections in China: Results from the study for monitoring antimicrobial resistance trends (SMART) 2018-2020.Epidemiology and infection · 2025Article
- Global incidence and risk factors for injury-related bloodstream infections: a scoping review.Epidemiologic reviews · 2025Article
- Bacteremia in the Gulf Cooperation Council Region: A Review of the Literature 2013-2023.Infection and drug resistance · 2025Review
- Microbial Epidemiology and Antimicrobial Resistance of Bloodstream Infections in Hospitalized Patients During 2019-2023 in Xiangyang, China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI.Frontiers in cellular and infection microbiology · 2025Article
- The Prognostic Role of Pitt Bacteremia Score in Patients With NonbacteremicThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- The Outcome of Hospital-Acquired Bloodstream Infection and Its Associated Factors in Critical Care Unit.The Malaysian journal of medical sciences : MJMS · 2024Article
- Impact of the COVID-19 pandemic on extended-spectrum β-lactamase producing Escherichia coli in urinary tract and blood stream infections: results from a nationwide surveillance network, Finland, 2018 to 2022.Antimicrobial resistance and infection control · 2024Article
- Development of two multiplex PCR assays for rapid detection of eleven Gram-negative bacteria in children with septicemia.Tropical medicine and health · 2024Article
- Comparing the Prognostic Impacts of Delayed Administration of Appropriate Antimicrobials in Older Patients with Afebrile and Febrile Community-Onset Bacteremia.Antibiotics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvancing age is a major risk factor for developing and dying from bloodstream infections (BSI). However, there is a paucity of population-based studies investigating the epidemiology of BSI in older persons.
objectiveTo define the incidence, clinical determinants, and risk factors for death among those aged 65 years and older with BSI.
methodsPopulation-based surveillance was conducted in the western interior of British Columbia, Canada, between April 1, 2010 and March 31, 2020. Chart reviews were conducted for clinical details and all cause case-fatality was established at 30-days follow-up.
resultsA total of 1854 incident BSI were identified among 1657 individuals aged 65 and older for an annual incidence of 533.9 per 100,000 population; the incidence for those aged 65-74, 75-84, and ≥85 years was 375.3, 678.9, and 1046.6 per 100,000 population, respectively. Males were at significantly increased risk as compared to females (incidence rate ratio, IRR 1.44; 95% confidence interval, CI, 1.32-1.59; p<0.0001). The crude annual incidence increased by 50% during the study. However, this was related to shift in population demographics with no increase evident following age- and sex-standardization. Older patients were more likely to have healthcare-associated infections and genitourinary sources and less likely to have bone/joint or soft tissue infections. The proportion of patients with underlying congestive heart failure, stroke, and dementia increased, whereas diabetes and liver disease decreased with older age. The overall 30-day all cause case-fatality rate was 22.0% (364/1657). After adjustment for clinical focus, onset of infection, etiology, and co-morbidity in a logistic model, those aged 75-84 years (odds ratio, OR, 1.66; 95% CI, 1.25-2.21) and ≥ 85 years (OR, 1.98; 95% CI, 1.41-2.77) were at significantly increased risk for death as compared to those aged 65-74 years.
conclusionBloodstream infection is common in older persons and is a major cause of death. Countries with aging populations worldwide should expect an increase burden associated with BSI in the coming years.
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