ArticlePloS one2021
Molecular analysis of blaSHV, blaTEM, and blaCTX-M in extended-spectrum β-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- High prevalence of ESBL encoding genes in enterobacterales isolated from hospital and environmental wastewater in Pakistan- One Health challenge.Molecular biology reports · 2026Article
- Virulence Traits and Drug Resistance of STEC Isolated from Layer Poultry andMicroorganisms · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Seasonal prevalence of extended-spectrum β-lactamase-producing bacteria in food-chain animals, humans, and the surrounding environment in Fayoum governorate: a one health approach.Frontiers in microbiology · 2026Article
- Antimicrobial resistance and molecular characterization of blaCTX-M-producing Escherichia coli isolated from broiler chickens in Peru.PloS one · 2026Article
- Analysis of Multi-Antimicrobial Resistance Patterns in U.S. Foodborne Pathogens (2015-2025) Using Data from the NCBI Pathogen Isolates Browser.Pathogens (Basel, Switzerland) · 2025Article
- Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.Scientific reports · 2025Article
- Effectiveness of Chitosan and Its Nanoparticles Against ampC- and ESBL-Producing Pan-Drug-ResistantPathogens (Basel, Switzerland) · 2025Article
- Comparative Analysis of Concentration and Quantification Methods for Antibiotic Resistance Genes and Their Phage-Mediated Dissemination in Treated Wastewater and Biosolids.Pathogens (Basel, Switzerland) · 2025Article
- Occurrence and Molecular Characterization of Extended-Spectrum Beta-Lactamase (ESBL)-ProducingAntibiotics (Basel, Switzerland) · 2025Article
- Unravelling mutation patterns in Extended-Spectrum β-Lactamases for precision drug design against AMR in Enterobacteriaceae.Molecular genetics and genomics : MGG · 2025Article
- Antibiotic resistance profiles in Gram-negative bacteria causing bloodstream and urinary tract infections in paediatric and adult patients in Ndola District, Zambia, 2020-2021.Infection prevention in practice · 2025Article
- The Microbiological Characteristics and Genomic Surveillance of Carbapenem-ResistantMicroorganisms · 2025Article
- High Antimicrobial Susceptibility of Cloacal Enterococci andAntibiotics (Basel, Switzerland) · 2025Article
- Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.PloS one · 2025Article
- Gut Microbial Composition and Antibiotic Resistance Profiles in Dairy Calves with Diarrhea.Life (Basel, Switzerland) · 2024Article
- Antimicrobial resistance of Escherichia coli in cats and their drinking water: drug resistance profiles and antimicrobial-resistant genes.BMC veterinary research · 2024Article
- The Rising Tide of Antibiotic Resistance: A Study on Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae.Journal of clinical laboratory analysis · 2024Article
- Molecular characterization of carbapenemase and extended spectrum beta-lactamase producing Acinetobacter baumannii isolates causing surgical site infections in Ethiopia.BMC infectious diseases · 2024Article
- Occurrence, Typing, and Resistance Genes of ESBL/AmpC-ProducingAntibiotics (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonization of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae as animal gut microbiota is a substantial global threat. This study aimed to determine the molecular characterization of blaSHV, blaTEM, and blaCTX-M variants in animals, as well as to evaluate the antimicrobial resistance conferred by these genes. We prospectively analyzed 1273 fecal specimens of farm and domestic animals for the isolation of enterobacteria that had the ESBL phenotype by using biochemical methods. The extracted genes were amplified by polymerase chain reaction and sequenced for the characterization of blaSHV, blaTEM, and blaCTX-M variants. The drug-resistance spectrum and hierarchical clusters were analyzed against 19 antibacterial agents. Out of 245 (19.2%) ESBL enterobacteria, 180 (75.5%) Escherichia coli and 34 (13.9%) Klebsiella pneumoniae were prevalent species. A total of 73.9% blaCTX-M, 26.1% blaTEM, and 14.2% blaSHV were found among the enterobacteria; however, their association with farm or domestic animals was not statistically significant. The distribution of bla gene variants showed the highest number of blaCTX-M-1 (133; 54.3%), followed by blaCTX-M-15 (28; 11.4%), blaTEM-52 (40; 16.3%), and blaSHV-12 (22; 9%). In addition, 84.5% of the enterobacteria had the integrons intI1. We observed ±100% enterobacteria resistant to cephalosporin, 7 (2.9%) to colistin (minimum inhibitory concentration breakpoint ≥4 μg/mL), 9 (3.7%) to piperacillin-tazobactam, 11 (4.5%) to imipenem, 14 (5.7%) to meropenem, and 18 (7.3%) to cefoperazone-sulbactam, without statistically significant association. Animal gut microbiota contain a considerable number of blaCTX-M, blaTEM, blaSHV, and integrons, which are a potential source of acquired extensive drug resistance in human strains and leaves fewer therapeutic substitutes.
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