ArticlePhysics in medicine and biology2021
Performance evaluation of the mouse version of the LabPET II PET scanner.
Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Simulation study of wedge-shaped light guide for compensating depth-of-interaction induced timing uncertainty in Cherenkov radiator.Medical physics · 2026Article
- Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Multi-Input Interaction Positioning and Signal Demultiplexing With Deep Learning in Semi-Monolithic Detectors.IEEE transactions on radiation and plasma medical sciences · 2026Article
- PET Imaging of the Human Brain with Microvolumetric Spatial Resolution.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Antibody-Based PET Imaging of Misfolded Superoxide Dismutase 1 in an Amyotrophic Lateral Sclerosis Mouse Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Performance Comparison of DOI-Encoding PET Detectors Based on 1.1-mm Pitch BGO Arrays With Different Reflectors.IEEE transactions on radiation and plasma medical sciences · 2024Article
- Submillimeter-Resolution PET for High-Sensitivity Mouse Brain Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The LabPET II is a new positron emission tomography technology platform designed to achieve submillimetric spatial resolution imaging using fully pixelated avalanche photodiodes-based detectors and highly integrated parallel front-end processing electronics. The detector was designed as a generic building block to develop devices for preclinical imaging of small to mid-sized animals and for clinical imaging of the human brain. The aim of this work is to assess the physical characteristics and imaging performance of the mouse version of LabPET II scanner following the NEMA NU4-2008 standard and using high resolution phantoms and in vivo imaging applications. A reconstructed spatial resolution of 0.78 mm (0.5 μ l) is measured close to the center of the radial field of view. With an energy window of 350 650 keV, the system absolute sensitivity is 1.2% and its maximum noise equivalent count rate reaches 61.1 kcps at 117 MBq. Submillimetric spatial resolution is achieved in a hot spot phantom and tiny bone structures were resolved with unprecedented contrast in the mouse. These results provide convincing evidence of the capabilities of the LabPET II technology for biomolecular imaging in preclinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.