Evidence map›Paper›PMID 33412235›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2021

Promising phytochemicals of traditional Indian herbal steam inhalation therapy to combat COVID-19 - An in silico study.

Shanmugaraj Gowrishankar, Sankar Muthumanickam, Arumugam Kamaladevi, Chandrasekar Karthika, Ravi Jothi, Pandi Boomi, Dharuman Maniazhagu, Shunmugiah Karutha Pandian

Open access · greenAbstract read
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 70 citations in OpenAlex.

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  11. Pseudoscience and fraudulent products for COVID-19 management.Environmental science and pollution research international · 2022
    Review
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  13. Article
  14. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
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  15. Article
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  19. Potential Multifunctional Bioactive Compounds fromJournal of inflammation research · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shanmugaraj GowrishankarDepartment of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India. Electronic address: gowrishankar.alu@gmail.com.
Sankar MuthumanickamDepartment of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
Arumugam KamaladeviDepartment of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Chandrasekar KarthikaDepartment of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
Ravi JothiDepartment of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
Pandi BoomiDepartment of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
Dharuman ManiazhaguDepartment of Physical Education & Health Sciences, Alagappa University, Karaikudi, India.
Shunmugiah Karutha PandianDepartment of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
Alagappa University · INBharathidasan University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19, the presently prevailing global public health emergency has culminated in international instability in economy. This unprecedented pandemic outbreak pressingly necessitated the trans-disciplinary approach in developing novel/new anti-COVID-19 drugs especially, small molecule inhibitors targeting the seminal proteins of viral etiological agent, SARS-CoV-2.

methodsBased on the traditional medicinal knowledge, we made an attempt through molecular docking analysis to explore the phytochemical constituents of three most commonly used Indian herbs in 'steam inhalation therapy' against well recognized viral receptor proteins.

resultsA total of 57 phytochemicals were scrutinized virtually against four structural protein targets of SARS-CoV-2 viz. 3CL

conclusionOverall, the data of the present study exemplifies that the phytochemicals from selected traditional herbs having significance in steam inhalation therapy would be promising in combating COVID-19.

Indexed as

Administration, InhalationComputer SimulationCOVID-19HumansMolecular Docking SimulationPhytochemicalsSARS-CoV-2SteamPhytochemicalsSteam3CL(pro)ACE-2COVID-19Herbal steam inhalation therapyIn silicoRdRpSARS-CoV-2Spike protein

Identifiers

PMID33412235
PMCPMC7780060
OpenAlexW3120321685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.