Evidence map›Paper›PMID 33412103›Full record

ReviewBiochemical pharmacology2021

P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications.

Lucas T Woods, Kevin Muñoz Forti, Vinit C Shanbhag, Jean M Camden, Gary A Weisman

Open access · greenAbstract readReview
In one paragraph

Review in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. P2YInternational journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Tumoral P2YPurinergic signalling · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Therapeutic potential for P2YPurinergic signalling · 2023
    Review
  20. The P2 purinoceptors in prostate cancer.Purinergic signalling · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lucas T WoodsDepartment of Biochemistry, University of Missouri, Columbia, MO, USA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Kevin Muñoz FortiDepartment of Biochemistry, University of Missouri, Columbia, MO, USA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Vinit C ShanbhagDepartment of Biochemistry, University of Missouri, Columbia, MO, USA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Jean M CamdenDepartment of Biochemistry, University of Missouri, Columbia, MO, USA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Gary A WeismanDepartment of Biochemistry, University of Missouri, Columbia, MO, USA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA. Electronic address: weismang@missouri.edu.
University of Missouri · US

Funding

VIP RECEPTORS AND SUBMANDIBULAR GLAND FUNCTIONR01DE007389 · NIDCR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WEISMAN, GARY ANDREW · 1988 to 2020
$7.6M
Restoring Salivary Gland Function by Reducing Nucleotide-induced InflammationR01DE023342 · NIDCR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WEISMAN, GARY ANDREW · 2014 to 2018
$2.9M
NIDCR NIH HHS R01 DE007389NIDCR NIH HHS R01 DE023342
6 · The paper itself

Abstract

Purinergic receptors for extracellular nucleotides and nucleosides contribute to a vast array of cellular and tissue functions, including cell proliferation, intracellular and transmembrane ion flux, immunomodulation and thrombosis. In mammals, the purinergic receptor system is composed of G protein-coupled P1 receptors A

Indexed as

Disease ProgressionAdenosine TriphosphateAnimalsAntineoplastic AgentsExtracellular FluidHumansNeoplasmsNucleotidesPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2YSignal TransductionAdenosine TriphosphateAntineoplastic AgentsNucleotidesPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2YCancerExtracellular nucleotidesMetastasisP2Y receptorsProliferationPurinergic receptors

Identifiers

PMID33412103
PMCPMC8096679
OpenAlexW3119258122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.