ArticleColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2021
Management guidelines for low anterior resection syndrome - the MANUEL project.
Article in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04936581 (Patient Reported Outcomes Following Cancer of the Rectum), which is not on this map. Cited by 76 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient Reported Outcomes Following Cancer of the Rectum
Who cites it
76 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Fecal incontinence after prostate cancer irradiation: a systematic literature review.Prostate cancer and prostatic diseases · 2026Pooled it
- Effectiveness of digital health interventions for the management of Low Anterior Resection Syndrome (LARS) after sphincter-preserving surgery for rectal cancer: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Psychosocial Interventions for Patients Undergoing Gastrointestinal Cancer Surgery: A Systematic Review.Annals of surgical oncology · 2026Pooled it
- Transanal irrigation: Bridging the gap in treatment for chronic constipation and/or faecal incontinence-A systematic review and management guidance.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- The Role of Patient Education in Low Anterior Resection Syndrome: A Systematic Review.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Pooled it
- Transanal irrigation is effective for low anterior resection syndrome: a systematic review and meta-analysis of randomized controlled trials.Techniques in coloproctology · 2025Pooled it
- Therapeutic strategies for low anterior resection syndrome: an umbrella review of systematic reviews.International journal of colorectal disease · 2025Pooled it
- Guideline
- A systematic review of preoperative radiological factors associated with the development of low anterior resection syndrome (LARS).Updates in surgery · 2025Pooled it
- Optimal interventions for low anterior resection syndrome: Bayesian network meta-analysis of randomized controlled trials.Techniques in coloproctology · 2025Pooled it
- Preventative strategies for low anterior resection syndrome.Techniques in coloproctology · 2023Pooled it
- The Role of Percutaneous Tibial Nerve Stimulation (PTNS) in Low Anterior Resection Syndrome (LARS): A Systematic Review and Meta-analysis.Journal of gastrointestinal cancer · 2023Pooled it
- Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at a Single Center.JMIR research protocols · 2026Trial
- Transanal irrigation for low anterior resection syndrome treatment: international multicentre randomized clinical trial.BJS open · 2026Trial
- The impact of an interactive online informational and peer support application (app) for patients with low anterior resection syndrome (LARS) on quality of life: a multicenter randomized controlled trial.Surgical endoscopy · 2025Trial
- Incremental Predictive Value of Conventional MRI Pelvimetry for Major Low Anterior Resection Syndrome After Rectal Cancer Surgery.Journal of clinical medicine · 2026Article
- Prevention, Recognition, and Management of Anastomotic Leakage and Pelvic Sepsis After Rectal Cancer Surgery: A Structured Narrative Review.Journal of clinical medicine · 2026Review
- The Process of Adapting to Altered Bowel Function in Patients With Rectal Cancer: A Grounded Theory Study.Psycho-oncology · 2026Article
- Article
- 'Everyone has their own way-there's no protocol'. An Australian qualitative study of clinician perspectives on the management of low anterior resection syndrome.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimLittle is known about the pathophysiology of low anterior resection syndrome (LARS), and evidence concerning the management of patients diagnosed with this condition is scarce. The aim of the LARS Expert Advisory Panel was to develop practical guidance for healthcare professionals dealing with LARS.
methodThe 'Management guidelines for low anterior resection syndrome' (MANUEL) project was promoted by a team of eight experts in the assessment and management of patients with LARS. After a face-to-face meeting, a strategy was agreed to create a comprehensive, practical guide covering all aspects that were felt to be clinically relevant. Eight themes were decided upon and working groups established. Each working group generated a draft; these were collated by another collaborator into a manuscript, after a conference call. This was circulated among the collaborators, and it was revised following the comments received. A lay patient revised the manuscript, and contributed to a section containing a patient's perspective. The manuscript was again circulated and finalized. A final teleconference was held at the end of the project.
resultsThe guidance covers all aspects of LARS management, from pathophysiology, to assessment and management. Given the lack of sound evidence and the often poor quality of the studies, most of the recommendations and conclusions are based on the opinions of the experts.
conclusionsThe MANUEL project provides an up-to-date practical summary of the available evidence concerning LARS, with useful directions for healthcare professional and patients suffering from this debilitating condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.