ArticlePloS one2021
Brain folding shapes the branching pattern of the middle cerebral artery.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Morphology and variations of middle cerebral artery: systematic review and meta-analysis.Anatomy & cell biology · 2024Review
- Morphology of middle cerebral artery using computed tomography angiographic study in a tertiary care hospital.Anatomy & cell biology · 2023Article
- Heterogeneous growth of the insula shapes the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mapping the branching pattern of the middle cerebral artery in the camel (Frontiers in veterinary science · 2023Article
- The microanatomy of the Sylvian fissure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.
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