ArticlePloS one2021
Exploring the influence of deforestation on dengue fever incidence in the Brazilian Amazonas state.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Machine learning and deep learning techniques to support clinical diagnosis of arboviral diseases: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Article
- Climate change and tropical medicine in the Amazon: contributions from a research center, gaps and future priorities.Revista da Sociedade Brasileira de Medicina Tropical · 2026Review
- Dengue Fever Resurgence in Iran: An Integrative Review of Causative Factors and Control Strategies.Tropical medicine and infectious disease · 2025Review
- Spatiotemporal Dynamics of Dengue in the State of Pará and the Socio-Environmental Determinants in Eastern Brazilian Amazon.Infectious disease reports · 2025Article
- Article
- Fatal yellow fever among captive non-human primates in southern Colombia, 2025.Frontiers in veterinary science · 2025Article
- The Impact of Human Activities on Zoonotic Infection Transmissions.Animals : an open access journal from MDPI · 2023Review
- Demographic and environmental factors associated with the distribution of Aedes albopictus in Cameroon.Medical and veterinary entomology · 2023Article
- Spatial Aspects of Health-Developing a Conceptual Framework.International journal of environmental research and public health · 2023Article
- Environmental Changes and the Impact on the Human Infections by Dengue, Chikungunya and Zika Viruses in Northern Brazil, 2010-2019.International journal of environmental research and public health · 2022Article
- The fewer, the better fare: Can the loss of vegetation in the Cerrado drive the increase in dengue fever cases infection?PloS one · 2022Article
- Review
- Integrating Spatial Modelling and Space-Time Pattern Mining Analytics for Vector Disease-Related Health Perspectives: A Case of Dengue Fever in Pakistan.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDengue fever is the most prevalent arboviral disease in the Brazilian Amazon and places a major health, social and economic burden on the region. Its association with deforestation is largely unknown, yet the clearing of tropical rainforests has been linked to the emergence of several infectious diseases, including yellow fever and malaria. This study aimed to explore potential drivers of dengue emergence in the Brazilian Amazon with a focus on deforestation.
methodsAn ecological study design using municipality-level secondary data from the Amazonas state between 2007 and 2017 (reported rural dengue cases, incremental deforestation, socioeconomic characteristics, healthcare and climate factors) was employed. Data were transformed according to the year with the most considerable deforestation. Associations were explored using bivariate analysis and a multivariate generalised linear model.
resultsDuring the study period 2007-2017, both dengue incidence and deforestation increased. Bivariate analysis revealed increased incidences for some years after deforestation (e.g. mean difference between dengue incidence before and three years after deforestation was 55.47 cases per 100,000, p = 0.002), however, there was no association between the extent of deforestation and dengue incidence. Using a negative binomial regression model adjusted for socioeconomic, climate and healthcare factors, deforestation was not found to be related to dengue incidence. Access to healthcare was found to be the only significant predictor of dengue incidence. DISCUSSION: Previous research has shown that deforestation facilitates the emergence of vector-borne diseases. However, no significant dose-response relationships between dengue incidence and deforestation in the Brazilian Amazonas state were found in this study. The finding that access to healthcare was the only significant predictor of dengue incidence suggests that incidence may be more dependent on surveillance than transmission. Further research and public attention are needed to better understand environmental effects on human health and to preserve the world's largest rainforest.
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