Evidence map›Paper›PMID 33411688›Full record

ArticleAging2020

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD.

Dongxue Ding, Chunrong Wang, Zhao Chen, Kun Xia, Beisha Tang, Rong Qiu, Hong Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dongxue DingDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Chunrong WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Kun XiaState Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, P.R. China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Rong QiuSchool of Information Science and Engineering, Central South University, Changsha, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation has recently been linked to transcriptional dysregulation and neuronal dysfunction in polyglutamine (polyQ) disease. This study aims to determine whether (CAG)

Indexed as

Ataxin-3Repressor ProteinsAnimalsDNA MethylationDNA Repeat ExpansionGene Expression RegulationHumansMaleMiceMice, TransgenicPeptidesAtaxin-3ATXN3 protein, humanAtxn3 protein, mousePeptidespolyglutamineRepressor ProteinsDNA methylationdynamic methylationgene expressionRRBSSCA3/MJD

Identifiers

PMID33411688
PMCPMC7906150
OpenAlexW3116092252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.