Evidence map›Paper›PMID 33411278›Full record

ArticleEnvironmental science and pollution research international2021

Ameliorative effect of graphene nanosheets against arsenic-induced toxicity in mice by oral exposure.

Huan Li, Bing Wu, Jingli Zhang, Yue Yu, Ling Chen, Su Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Huan LiDepartment of Environmental Science, School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, People's Republic of China.
Bing WuState Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, People's Republic of China.
Jingli ZhangDepartment of Environmental Science, School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, People's Republic of China.
Yue YuState Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, People's Republic of China.
Ling ChenState Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, People's Republic of China.
Su LiuDepartment of Environmental Science, School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, People's Republic of China. suliu@cpu.edu.cn.
State Key Laboratory of Pollution Control and Resource Reuse · CNChina Pharmaceutical University · CNNanjing University · CN

Funding

Fundamental Research Funds for the Central Universities 2632020ZD12Innovation and Entrepreneurship Training Program for Undergraduate 201910316217National Natural Science Foundation of China 21806078National Natural Science Foundation of China (CN) 21577061Natural Science Foundation of Jiangsu Province (CN) BK20170633State Key Laboratory of Pollution Control and Resource Reuse Foundation PCRRF18008
6 · The paper itself

Abstract

Arsenic is a highly toxic environmental pollutant that is abundant in waters around the world. Previous studies have indicated that the toxicity of arsenic can be affected by co-exposure to chemicals. As a promising two-dimensional nanomaterial, graphene has received extensive attention in recent years. Owing to the wide application of graphene, its co-exposure with arsenic increases significantly. However, little information is available on the combined toxicity of graphene and arsenic. This study aimed to investigate the effects of graphene on arsenic-induced toxicity by oral exposure in mice. The results showed that the addition of graphene significantly reduced the toxicity of arsenic in the intestine and liver of mice, and the high-concentration graphene exhibited greater toxicity reduction effects. Graphene significantly decreased the bioavailability of arsenic because of its adsorption capability and spatial structure. In addition, graphene adhered to the intestinal tract may also prevent arsenic from passing through the intestinal epithelium freely. Moreover, graphene also affected arsenic toxicity through enhanced metabolism transformation by changing the gut microbiota. This study provides a comprehensive understanding of the combined toxicity of graphene and arsenic.

Indexed as

ArsenicArsenic PoisoningGastrointestinal MicrobiomeGraphiteAnimalsLiverMiceArsenicGraphiteArsenicBioavailabilityCombined toxicityGrapheneGut microbiotaOxidative stress

Identifiers

PMID33411278
OpenAlexW3119580693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.