ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Changes in corticomotor pathway excitability after exercise training in Parkinson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Supervised-not voluntary-upper limb exercise enhances vestibular function in Parkinson's disease.Frontiers in neurology · 2025Article
- Exercise Improves Movement by Regulating the Plasticity of Cortical Function in Hemiparkinsonian Rats.Frontiers in aging neuroscience · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAltered corticospinal excitability in Parkinson's disease (PD) is related to many of the motor signs.
objectiveWe examined whether the recruitment properties of the corticospinal pathway to hand muscles are changed after 8 weeks of specialized upper limbs exercise in PD.
methodsSeven PD subjects were enrolled. Upper limb exercise was achieved by using a specially designed device. The input-output (I-O) curves were obtained by transcranial magnetic stimulation (TMS). The conduction of peripheral axons and H reflex was also recorded. UPDRS scale, part-III motor examination was used to assess the motor symptom. Clinical and neurophysiological data were obtained before and after 2-month exercise training.
resultsAfter 2-month exercise training, the UPDRS score was significantly improved. Threshold, slope, and V50 (i.e., the stimulus intensity required to obtain a response 50% of the maximum) of the I-O curve were unchanged, whereas the plateau value was significantly higher.
conclusionsExercise training affects the larger motoneurons, that is those activated at higher TMS stimulation intensity. These motoneurones are related to the large, type II motor units. Clinical improvement after exercise may depend upon restoration of the recruitment of the large motor unit, i.e., those necessary to perform rapid and strong movements, known to be deficient in PD.
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