ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Imaging and depression in multiple sclerosis: a historical perspective.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- A systematic review and meta-analysis of socio-cognitive impairments in multiple sclerosis.Scientific reports · 2024Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Affective reserve in older adults with and without multiple sclerosis: A residual-based approach.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- MRI Correlates of Depression and Anxiety in Multiple Sclerosis.Diseases (Basel, Switzerland) · 2026Review
- Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis.Journal of biomedical physics & engineering · 2026Article
- From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis.Journal of neurology · 2025Article
- Fatigue, Insomnia, and Disability as Independent Predictors of Depressive Symptoms in Multiple Sclerosis: A Prospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Fatigue and its correlation with anxiety and depression in patients with multiple sclerosis in China.Frontiers in neurology · 2025Article
- Review
- Natural Language Processing for Depression Prediction on Sina Weibo: Method Study and Analysis.JMIR mental health · 2024Article
- Depression and anxiety in multiple sclerosis. Review of a fatal combination.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis.Journal of neurology · 2024Article
- Post-Stroke Depression in Older Adults: An Overview.Drugs & aging · 2024Review
- Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients.BMC psychology · 2023Article
- Lesion network localization of depression in multiple sclerosis.Nature. Mental health · 2023Article
- The impact of therapeutic education programs on the quality of life of patients with multiple sclerosis: Protocol of a systematic review.Journal of education and health promotion · 2023Review
- Oral health-related quality of life is more strongly correlated with mental health than with oral health in relapsing-remitting multiple sclerosis.Journal of oral rehabilitation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients affected with multiple sclerosis suffer from depression more frequently than the general population. Beyond psychosocial, genetic and immune-inflammatory factors, also the brain damage which is peculiar of multiple sclerosis has been claimed to have a role in the aetiology of depression in those patients. The study of this interesting relation has been implemented with both conventional and advanced magnetic resonance imaging techniques. The aim of this review is to provide a historical perspective on the link between multiple sclerosis-related depression and structural and functional brain damage.
methodsIn this review, the results of the MRI studies regarding multiple sclerosis-related brain damage and the presence of depression are presented.
resultsThe findings of the reports reveal a link between brain pathology and depressive symptoms or the diagnosis of depression in multiple sclerosis.
conclusionsAlthough a multifactorial aetiology has been theorized for depression and depressive symptoms in patients with multiple sclerosis, this review supports the hypothesis that the structural and functional brain impairment might substantially be amongst those factors. Thus, depression itself might be a symptom with a neuro-biological basis and not only the consequence of the disability derived from the neurological impairment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.