ArticleInternational urology and nephrology2021
The retrospective study of perioperative application of dexamethasone and furosemide for postoperative anti-inflammation in patients undergoing percutaneous nephrolithotomy.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- The Impact of Intraoperative Dexamethasone and Mannitol on Postoperative Inflammatory Response in Totally Tubeless Percutaneous Nephrolithotomy: A Prospective, Double-Blind, Controlled Clinical Trial.Advances in urology · 2026Article
- Safety and efficacy of total tubeless mini-PCNL in the management of renal stones: prospective observational study.BMC urology · 2025Observational
- Pain management in percutaneous nephrolithotomy - an approach rooted in pathophysiology.Nature reviews. Urology · 2025Review
- Article
- Is negative urine culture necessary for PCNL safety? Experience from a large-volume stone center.Frontiers in surgery · 2025Article
- Article
- Effect of dexamethasone pretreatment using deep learning on the surgical effect of patients with gastrointestinal tumors.PloS one · 2024Article
- One-stage tubeless percutaneous nephrolithotomy for asymptomatic calculous pyonephrosis.BMC urology · 2022Article
- Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response.International journal of molecular sciences · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate whether the perioperatively combined application of dexamethasone and furosemide could alleviate the inflammation in patients undergoing percutaneous nephrolithotomy (PCNL). PATIENTS AND
methods147 patients undergoing PCNL between November 2018 and October 2019 were enrolled in the study. 77 patients accepted a single dose of dexamethasone and furosemide administration (EXP group, n = 77), and 70 patients did not (CON group, n = 70). Demographic and perioperative data, inflammatory markers including interleukin-6 (IL-6) and procalcitonin (PCT), and clinical outcomes were compared between the two groups.
resultsCompared with the CON group, the incidence rate of urosepsis of the EXP group were significantly lower (11.69% vs. 24.29%, p = 0.046). 3 patients developed severe urosepsis in the EXP group, while 5 patients developed severe urosepsis in the CON group. Compared with those in the CON group, the patients with postoperative urosepsis in the EXP group showed lower serum levels of IL-6 at postoperative hour two (p = 0.045) and at postoperative day one (p = 0.031) and lower serum levels of PCT at postoperative day one (p = 0.015). There was a better clinical outcome of a shorter postoperative hospital stay (p = 0.015) in patients with postoperative urosepsis in the EXP group than in those in the CON group.
conclusionThe perioperatively combined application of dexamethasone and furosemide was beneficial for alleviating postoperative inflammatory reaction and caused a better clinical outcome of a shorter postoperative hospital stay.
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