ReviewCancer immunology, immunotherapy : CII2021
Immunologic factors involved in the malignant transformation of endometriosis to endometriosis-associated ovarian carcinoma.
Review in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Endometriosis and Endometrial Cancer-Association Between Biological Mechanisms and Its Clinical Implications.Journal of clinical medicine · 2026Review
- Tumor-intrinsic B4GALNT3 expression drives a protective immune microenvironment in endometriosis-associated ovarian cancer.Translational cancer research · 2026Article
- Endometriosis and the Hallmarks of Cancer.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Role of small extracellular-vesicle microRNA-302f in endometriosis-associated ovarian cancer.Discover oncology · 2025Article
- From Inflammation to Malignancy: The Link Between Endometriosis and Gynecological Cancers.International journal of molecular sciences · 2025Review
- Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Endometriosis and Ovarian Cancer: Insights from NHANES and Mendelian Randomization Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Overexpression of FOS enhances the malignant potential of eutopic endometrial stromal cells in patients with endometriosis‑associated ovarian cancer.Oncology reports · 2025Article
- Endometriosis and autoimmunity.Autoimmunity reviews · 2025Review
- The independent and joint associations of hysterectomy and uterine fibroids or endometriosis with ovarian cancer incidence: results from a US-based cohort.American journal of epidemiology · 2025Article
- The expression of autophagy-related gene CXCL12 in endometriosis associated ovarian cancer and pan-cancer analysis.Frontiers in endocrinology · 2025Article
- Female reproductive disease, endometriosis: From inflammation to infertility.Molecules and cells · 2025Review
- Bioinformatic and experimental data pertaining to the role of the NLRP3 inflammasome in ovarian cancer.Journal of cancer research and clinical oncology · 2024Review
- Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Review
- Research progress in endometriosis-associated ovarian cancer.Frontiers in oncology · 2024Review
- Evaluation of Immune Infiltrates in Ovarian Endometriosis and Endometriosis-Associated Ovarian Cancer: Relationship with Histological and Clinical Features.International journal of molecular sciences · 2023Article
- A comprehensive overview of exosome lncRNAs: emerging biomarkers and potential therapeutics in endometriosis.Frontiers in endocrinology · 2023Review
- Clear cell carcinoma of the abdominal wall: A case report with a review of the literature.Annals of medicine and surgery (2012) · 2022Article
- Labile Heme and Heme Oxygenase-1 Maintain Tumor-Permissive Niche for Endometriosis-Associated Ovarian Cancer.Cancers · 2022Article
- Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEndometriosis is a risk factor for low-grade serous, clear cell, and endometroid ovarian carcinoma. In both endometriosis and ovarian carcinoma, immunological factors are associated with clinical outcome. Chronic inflammation in endometriosis may be linked to tumorigenesis, but exact processes contributing to endometriosis-associated ovarian carcinoma remain unknown. This review aims to describe potential immunological factors involved in the malignant transformation of endometriosis into ovarian carcinoma.
methodsPubMed and Embase were searched from inception up to October 2020 for studies comparing immunological processes in endometriosis and endometriosis-associated ovarian carcinoma.
resultsDetailed analysis of immune components in the malignant transformation of endometriosis into endometriosis-associated ovarian carcinoma is lacking. Altered levels of chemokines and cytokines as IL-6, IL-8, IL-10, and TNF-α are reported and the function, number and polarization of NK cells, dendritic cells, and monocytes differ between endometriosis and associated ovarian carcinoma compared to healthy tissue. In addition, altered inflammasome and complement systems, indicate a role for the immune system in the carcinogenesis of endometriosis.
conclusionChronic inflammation in endometriosis may potentially drive inflammation-induced carcinogenesis in endometriosis-associated ovarian carcinoma. Exact immunological pathways and cellular processes remain unknown and require more thorough investigation.
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