Evidence map›Paper›PMID 33411075›Full record

ArticleGlycoconjugate journal2021

Structural analysis of glycosaminoglycans from Oviductus ranae.

Haiyue Huang, Jin Mao, Quntao Liang, Jianghui Lin, Lilong Jiang, Shutao Liu, Joshua S Sharp, Zheng Wei

Abstract read
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In one paragraph

Article in Glycoconjugate journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Haiyue HuangInstitute of Glycobiochemistry, National Engineering Research Centre of Chemical Fertilizer Catalyst, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Jin MaoInstitute of Glycobiochemistry, National Engineering Research Centre of Chemical Fertilizer Catalyst, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Quntao LiangCollege of Biological Science and Engineering, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Jianghui LinInstitute of Glycobiochemistry, National Engineering Research Centre of Chemical Fertilizer Catalyst, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Lilong JiangInstitute of Glycobiochemistry, National Engineering Research Centre of Chemical Fertilizer Catalyst, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Shutao LiuCollege of Biological Science and Engineering, Fu Zhou University, Fu Zhou, 350002, People's Republic of China.
Joshua S SharpDepartment of BioMolecular Sciences, Department of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, 38655, USA.
Zheng WeiInstitute of Glycobiochemistry, National Engineering Research Centre of Chemical Fertilizer Catalyst, Fu Zhou University, Fu Zhou, 350002, People's Republic of China. zheng0wei@hotmail.com.ORCID 0000-0001-6469-6711
Institute of Applied Physics · UAUniversity of Mississippi · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oviductus ranae (O.ran.) has been widely used as a tonic and a traditional animal-based Chinese medicine. O.ran. extracts have been reported to have numerous biological activities, including activities that are often associated with mammalian glycosaminoglycans such as anti-inflammatory, antiosteoperotic, and anti-asthmatic. Glycosaminoglycans are complex linear polysaccharides ubiquitous in mammals that possess a wide range of biological activities. However, their presence and possible structural characteristics within O.ran. were previously unknown. In this study, glycosaminoglycans were isolated from O.ran. and their disaccharide compositions were analyzed by liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-MS-ITTOF). Heparan sulfate (HS)/heparin (HP), chondroitin sulfate (CS)/dermatan sulfate (DS) and hyaluronic acid (HA) were detected in O.ran. with varied disaccharide compositions. HS species contain highly acetylated disaccharides, and have various structures in their constituent chains. CS/DS chains also possess a heterogeneous structure with different sulfation patterns and densities. This novel structural information could help clarify the possible involvement of these polysaccharides in the biological activities of O.ran..

Indexed as

Chondroitin SulfatesChromatography, LiquidDermatan SulfateDisaccharidesGlycosaminoglycansHeparan SulfateHeparinMass SpectrometryMateria MedicaSensitivity and SpecificityChondroitin SulfatesDermatan Sulfatedermatan sulfate chondroitin sulfateDisaccharidesGlycosaminoglycansHeparan SulfateHeparinMateria MedicaOviductus RanaeChondroitin sulfateDermatan sulfateHyaluronic acidLC-MS-ITTOFOviductus ranae

Identifiers

PMID33411075
OpenAlexW3120679576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.