ArticleEuropean radiology2021
Contrast-enhanced ultrasound: a valuable modality for extracapsular extension assessment in papillary thyroid cancer.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Diagnostic value of contrast-enhanced ultrasound combined with other imaging techniques in differentiating benign and malignant thyroid nodules: a network meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Meta-Analysis of Contrast Enhanced Ultrasound in Judging Benign and Malignant Thyroid Tumors.Computational and mathematical methods in medicine · 2021Pooled it
- Article
- Predicting malignancy in solid thyroid nodules with no or punctate-linear enhancement on contrast-enhanced ultrasound: a retrospective analysis.Quantitative imaging in medicine and surgery · 2026Article
- Contrast-enhanced ultrasound time-intensity curve-assisted parametric imaging: a possible effective tool for differential diagnosis of thyroid nodules.Gland surgery · 2026Article
- Synthesize contrast-enhanced ultrasound image of thyroid nodules via generative adversarial networks.European radiology · 2026Article
- Prediction of lymph node metastasis in cN0 papillary thyroid carcinoma using a random forest-based radiomics model integrating contrast-enhanced ultrasound and clinical data.Frontiers in oncology · 2026Article
- Utility of quantitative contrast-enhanced ultrasound: a valuable prediction for capsule invasion assessment in papillary thyroid cancer.Quantitative imaging in medicine and surgery · 2025Article
- Early prediction of thyroid capsule invasion in papillary microcarcinoma using ultrasound-based deep learning models: a retrospective multicenter study.Insights into imaging · 2025Article
- Development and validation of the multidimensional machine learning model for preoperative risk stratification in papillary thyroid carcinoma: a multicenter, retrospective cohort study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Contrast-enhanced ultrasound combined with shear wave elastography in the diagnosis of C-TIRADS category 4 thyroid nodules.Quantitative imaging in medicine and surgery · 2025Article
- Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features.BMC cancer · 2025Article
- A risk stratification model based on ultrasound radiologic features for cervical metastatic lymph nodes in papillary thyroid cancer.World journal of surgical oncology · 2025Article
- Role of Ultrasound Elastography and Contrast-Enhanced Ultrasound (CEUS) in Diagnosis and Management of Malignant Thyroid Nodules-An Update.Diagnostics (Basel, Switzerland) · 2025Review
- Thermal Ablation for Papillary Thyroid Carcinoma.JAMA otolaryngology-- head & neck surgery · 2024Article
- Application of color doppler ultrasound and US shear wave elastography with connective tissue growth factor in the risk assessment of papillary thyroid carcinoma.BMC medical imaging · 2024Article
- Radiofrequency ablation for capsular-located versus noncapsular-located papillary thyroid microcarcinoma: a propensity score matching study of 1095 patients.European radiology · 2024Article
- Evaluation of parietal pleural adhesion and invasion in subpleural lung cancer: value of B-mode ultrasound and contrast-enhanced ultrasound.Quantitative imaging in medicine and surgery · 2024Article
- The feasibility of using a multivariate regression model incorporating ultrasound findings and serum markers to predict thyroid cancer metastasis.Frontiers in endocrinology · 2024Article
- Preoperative prediction of extrathyroidal extension: radiomics signature based on multimodal ultrasound to papillary thyroid carcinoma.BMC medical imaging · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo evaluate the diagnostic accuracy of preoperative contrast-enhanced ultrasound (CEUS) to detect extracapsular extension (ECE) and identify the relationship between ECE and nodule enhancement patterns in patients with papillary thyroid cancer (PTC).
methodsPatients with suspected thyroid cancer underwent ultrasound (US) and CEUS examinations. The US and CEUS features of the PTC nodules and thyroid capsule were recorded and classified individually. The accuracy of US and CEUS in detecting ECE was compared individually, and its relationship with various tumour enhancement patterns was analysed. The presence or absence of ECE and cervical lymph node metastasis (LNM) was confirmed pathologically.
resultsThe final dataset included 119 patients with 124 PTC nodules. Seventy-two (60.5%) of these patients with PTC had no ECE (including 38 patients with single capsule invasion), while the remaining 52 had ECE. A significant difference was found in nodules with non-capsule invasion, single capsule invasion, and ECE between the cervical LNM and non-LNM groups (p < 0.01). Receiver operating characteristic curve analysis demonstrated that area under the curve (AUC) of ECE for cervical LNM was higher than that of capsule invasion (71.9% vs. 49.6%). Moreover, the CEUS images acquired to detect ECE showed higher AUC values than those of US images (79.4% vs. 65.8%) (p = 0.02). Among the PTC nodules with differential enhancement, hyper-enhanced nodules had the highest incidence of capsule invasion (41.9%), while hypo-enhanced ones had a higher incidence of ECE (47.4%).
conclusionsCompared with conventional US, CEUS is a more valuable and non-invasive imaging modality to detect ECE. KEY POINTS: • Single capsular invasion was a poor predictor of cervical lymph node metastasis, while extracapsular extension assessments were clinically significant for predicting cervical lymph node metastasis. • CEUS is better than conventional US in detecting extracapsular extension in papillary thyroid carcinoma (AUC: 79.4% vs. 65.8%) (p = 0.02). • Among the thyroid papillary carcinoma nodules with differential enhancement, hyper-enhanced nodules had the highest incidence of single capsule invasion (41.9%), while hypo-enhanced ones had a higher incidence of ECE (47.4%).
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