Evidence map›Paper›PMID 33411048›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review.

Elisa Kauark-Fontes, Leticia Rodrigues-Oliveira, Joel B Epstein, Karina Morais Faria, Anna Luiza Damaceno Araújo, Luiz Alcino Monteiro Gueiros, Cesar Augusto Migliorati, Ramzi G Salloum, Patricia Burton, James Carroll and 6 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Clinical use of photobiomodulation as a supportive care during radiation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Elisa Kauark-Fontes *Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0001-7375-379X
Leticia Rodrigues-Oliveira *Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-5775-6090
Joel B EpsteinCedars-Sinai Health System, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9264-9151
Karina Morais FariaDental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-8795-5146
Anna Luiza Damaceno AraújoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-3725-8051
Luiz Alcino Monteiro GueirosClinical and Preventive Dentistry Department, Universidade Federal de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0003-4979-4318
Cesar Augusto MiglioratiCollege of Dentistry, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0002-2535-2606
Ramzi G SalloumCollege of Medicine, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0002-8139-2418
Patricia BurtonTHOR Photomedicine Ltd, Chesham, Buckinghamshire, UK.ORCID https://orcid.org/0000-0002-0103-358X
James CarrollTHOR Photomedicine Ltd, Chesham, Buckinghamshire, UK.ORCID https://orcid.org/0000-0002-9205-1061
Marcio Ajudarte LopesOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0001-6677-0065
Carolina Guimarães Bonfim AlvesOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0003-3526-4201
Natalia Rangel PalmierOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0001-9588-6227
Ana Carolina Prado-RibeiroOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-0127-7998
Thaís Bianca BrandãoDental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0001-9128-3138
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil. alanroger@fop.unicamp.br.ORCID https://orcid.org/0000-0003-2040-6617
Universidade Estadual de Campinas (UNICAMP) · BRInstituto do Câncer do Estado de São Paulo · BRUniversity of Florida · USCity of Hope · USUniversidade Federal de Pernambuco · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) Research granteeFundação de Amparo à Pesquisa do Estado de São Paulo (BR) 2018/02233-6Fundação de Amparo à Pesquisa do Estado de São Paulo (BR) 2018/04657-8Fundação de Amparo à Pesquisa do Estado de São Paulo (BR) 2018/23479-3
6 · The paper itself

Abstract

purposeTo identify and summarize the evidence on the cost-effectiveness of photobiomodulation (PBM) therapy for the prevention and treatment of cancer treatment-related toxicities.

methodsThis systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) and Meta-analysis Of Observational Studies in Epidemiology (MOOSE). Scopus, MEDLINE/PubMed, and Embase were searched electronically.

resultsA total of 1490 studies were identified, and after a two-step review, 4 articles met the inclusion criteria. The included studies analyzed the cost-effectiveness of PBM therapy used in the context of lymphedema for breast cancer and oral mucositis (OM) induced by chemotherapy and radiotherapy. Better outcomes were associated with PBM therapy. The incremental cost-effectiveness ratio ranged from 3050.75 USD to 5592.10 USD per grade 3-4 OM case prevented. PBM therapy cost 21.47 USD per percentage point reduction in lymphedema in comparison with 80.51 USD for manual lymph drainage and physical therapy.

conclusionThere is limited evidence that PBM therapy is cost-effective in the prevention and treatment of specific cancer treatment-related toxicities, namely, OM and breast cancer-related lymphedema. Studies may have underreported the benefits due to a lack of a comprehensive cost evaluation. This suggests a wider acceptance of PBM therapy at cancer treatment centers, which has thus far been limited by the number of robust clinical studies that demonstrate cost-effectiveness for the prevention and treatment of toxicities.

Indexed as

Cost-Benefit AnalysisHumansLow-Level Light TherapyNeoplasmsCancer toxicitiesCostPhotobiomodulationSystematic review

Identifiers

PMID33411048
OpenAlexW3119305991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.