Evidence map›Paper›PMID 33411034›Full record

ArticleEJNMMI radiopharmacy and chemistry2021

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE.

Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, Brian Hook, Mikael Jensen, Amir Kassaian, Stefan Zeisler, Sogol Borjian, Michael Cross and 2 more

Abstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. ExpandingEJNMMI radiopharmacy and chemistry · 2026
    Article
  2. Article
  3. Pharmaceutics · 2025
    Review
  4. [Current radiopharmaceuticals · 2025
    Article
  5. A comparison of routine [EJNMMI radiopharmacy and chemistry · 2024
    Article
  6. Advances in Radioligand Theranostics in Oncology.Molecular diagnosis & therapy · 2024
    Review
  7. Article
  8. Fully automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  9. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  10. Review
  11. Recovery of Gallium-68 and Zinc from HNOMolecules (Basel, Switzerland) · 2022
    Article
  12. Good practices forEJNMMI radiopharmacy and chemistry · 2022
    Review
  13. Preparation and Evaluation of [Molecules (Basel, Switzerland) · 2022
    Article
  14. Analysis of Pros and Cons in Using [Molecules (Basel, Switzerland) · 2022
    Article
  15. Article
  16. European journal of nuclear medicine and molecular imaging · 2022
    Article
  17. Article
  18. Automated light-induced synthesis ofScientific reports · 2022
    Article
  19. Cold Kit Labeling: The Future ofFrontiers in medicine · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Helge ThisgaardDepartment of Nuclear Medicine, Odense University Hospital, Kløvervænget 47, 5000, Odense, Denmark. helge.thisgaard@rsyd.dk.ORCID http://orcid.org/0000-0001-9492-448X
Joel KumlinARTMS, Vancouver, BC, Canada.
Niels LangkjærDepartment of Nuclear Medicine, Odense University Hospital, Kløvervænget 47, 5000, Odense, Denmark.
Jansen ChuaARTMS, Vancouver, BC, Canada.
Brian HookARTMS, Vancouver, BC, Canada.
Mikael JensenThe Hevesy Laboratory, Health Technology, Technical University of Denmark, Roskilde, Denmark.
Amir KassaianARTMS, Vancouver, BC, Canada.
Stefan ZeislerARTMS, Vancouver, BC, Canada.
Sogol BorjianARTMS, Vancouver, BC, Canada.
Michael CrossARTMS, Vancouver, BC, Canada.
Paul SchafferARTMS, Vancouver, BC, Canada.
Johan Hygum DamDepartment of Nuclear Medicine, Odense University Hospital, Kløvervænget 47, 5000, Odense, Denmark.ORCID http://orcid.org/0000-0001-6577-7011

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([

resultsEnriched zinc-68 targets were irradiated at up to 80 µA with 13 MeV protons for 120 min; repeatedly producing up to 194 GBq (5.24 Ci) of purified gallium-68 in the form of [

conclusionsWe have developed a high-yielding, automated method for the production of very high amounts of [

Indexed as

AcceleratorCyclotronDOTATATEGallium-68PSMA-11Solid targetTargetry

Identifiers

PMID33411034
PMCPMC7790954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.