ArticlePsychopharmacology2021
Prescription opioid misusers exhibit blunted parasympathetic regulation during inhibitory control challenge.
Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Opioid Craving in Chronic Pain Management: A Structural Equation Model of Veterans in Pain Rehabilitation.Military medicine · 2026Observational
- Opioid misuse detection from cognitive and physiological data with temporal fusion deep learning.Drug and alcohol dependence · 2025Article
- Negative affectivity drivers of impulsivity in opioid use disorder.Nature reviews. Psychology · 2025Article
- Exploring the use of Granger causality for the identification of chemical exposure based on physiological data.Frontiers in network physiology · 2023Article
- Association between opioid use disorder and blunted heart rate variability among opioid-treated chronic pain patients.Addiction biology · 2022Article
- Article
- Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.Drug and alcohol dependence · 2022Article
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Authors and funding
2 authors.
Funding
Abstract
rationaleAmong opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse.
objectivesUsing high-frequency heart rate variability (HF-HRV) to index-impaired response inhibition, we examined associations between opioid misuse and response inhibition in emotional and neutral contexts in a sample of opioid-treated chronic pain patients.
methodChronic pain patients taking opioid analgesics (N = 97) for ≥ 90 days completed an Emotional Go/NoGo task that presented an inhibitory control challenge in the context of neutral, opioid, negative affective, and positive affective background images while HF-HRV was computed. Opioid misuse and craving were assessed. Using a validated cut-point on the Current Opioid Misuse Measure, participants were classified as opioid misusers or non-misusers. Opioid misuse was examined as a predictor of behavioral and HF-HRV metrics of response inhibition.
resultsNegative affective and opioid images elicited more errors of commission (p = .002, η
conclusionReduced parasympathetic regulation during inhibitory control challenge may indicate heightened opioid misuse risk among opioid-treated chronic pain patients.
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