Evidence map›Paper›PMID 33410917›Full record

ArticleThe Journal of clinical endocrinology and metabolism2021

Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers.

Osagie Ebekozien, Shivani Agarwal, Nudrat Noor, Anastasia Albanese-O'Neill, Jenise C Wong, Tossaporn Seeherunvong, Janine Sanchez, Daniel DeSalvo, Sarah K Lyons, Shideh Majidi and 17 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Unspoken Consequences of Structural Racism in the USA: Diabetes and COVID-19.Journal of racial and ethnic health disparities · 2024
    Review
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  19. Diabetes Technology Meeting 2021.Journal of diabetes science and technology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 19 institutions in 1 country.

Osagie EbekozienT1D Exchange, Boston, MA, USA.
Shivani AgarwalFleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, USA.
Nudrat NoorT1D Exchange, Boston, MA, USA.
Anastasia Albanese-O'NeillUniversity of Florida, Gainesville, FL, USA.
Jenise C WongMadison Clinic for Pediatric Diabetes, University of California San Francisco, CA, USA.
Tossaporn SeeherunvongMiller School of Medicine, University of Miami, Maimi, FL, USA.
Janine SanchezMiller School of Medicine, University of Miami, Maimi, FL, USA.
Daniel DeSalvoTexas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.
Sarah K LyonsTexas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.
Shideh MajidiBarbara Davis Center for Diabetes, University of Colorado, Denver, CO, USA.
Jamie R WoodUH Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Runa AcharyaSUNY Upstate Medical University, NY, USA.
Grazia AleppoFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kathryn M SumpterLe Bonheur Children's Hospital, University of Tennesse Health Science Center, Memphis, Tennesse, TN, USA.
Anna CymbalukTexas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.
Nirali A ShahIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle Van NameYale School of Medicine, New Haven, CT, USA.
Lisa Cruz-AvilesYale School of Medicine, New Haven, CT, USA.
Guy Todd AlonsoBarbara Davis Center for Diabetes, University of Colorado, Denver, CO, USA.
Mary Pat GallagherHassenfeld Children's Hospital, NYU Langone, New York, NY, USA.
Srinath SandaMadison Clinic for Pediatric Diabetes, University of California San Francisco, CA, USA.
Alexis Jamie FeuerDivision of Pediatric Endocrinology, Weill Cornell Medicine, New York, NY, USA.
Kristina CossenChildren's Hospital of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
Nicole RiolesT1D Exchange, Boston, MA, USA.
Nana-Hawa Yayah JonesCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Manmohan K KambojNationwide Children Hospital, Columbus, OH, USA.
Irl B HirschUniversity of Washington Diabetes Institute, Seattle, WA, USA.
Baylor College of Medicine · UST1D Exchange · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Miami · USYale University · USAlbert Einstein College of Medicine · USCincinnati Children's Hospital Medical Center · USCornell University · USEmory University · USIcahn School of Medicine at Mount Sinai · USLe Bonheur Children's Hospital · USNationwide Children's Hospital · USNorthwestern University · USNYU Langone Health · USRainbow Babies & Children's Hospital · USSUNY Upstate Medical University · USUniversity of Florida · USUniversity of Washington · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DONALD K. SCOTT · 2015 to 2026
$27.7M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Identifying and Reducing Disparities in Outcomes Among Economically Vulnerable and Minority Young Adults with Type 1 DiabetesK23DK115896 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AGARWAL, SHIVANI · 2018 to 2022
$988k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K23 DK115896NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

objectiveWe examined whether diabetic ketoacidosis (DKA), a serious complication of type 1 diabetes (T1D) was more prevalent among Non-Hispanic (NH) Black and Hispanic patients with T1D and laboratory-confirmed coronavirus disease 2019 (COVID-19) compared with NH Whites.

methodThis is a cross-sectional study of patients with T1D and laboratory-confirmed COVID-19 from 52 clinical sites in the United States, data were collected from April to August 2020. We examined the distribution of patient factors and DKA events across NH White, NH Black, and Hispanic race/ethnicity groups. Multivariable logistic regression analysis was performed to examine the odds of DKA among NH Black and Hispanic patients with T1D as compared with NH White patients, adjusting for potential confounders, such as age, sex, insurance, and last glycated hemoglobin A1c (HbA1c) level.

resultsWe included 180 patients with T1D and laboratory-confirmed COVID-19 in the analysis. Forty-four percent (n = 79) were NH White, 31% (n = 55) NH Black, 26% (n = 46) Hispanic. NH Blacks and Hispanics had higher median HbA1c than Whites (%-points [IQR]: 11.7 [4.7], P < 0.001, and 9.7 [3.1] vs 8.3 [2.4], P = 0.01, respectively). We found that more NH Black and Hispanic presented with DKA compared to Whites (55% and 33% vs 13%, P < 0.001 and P = 0.008, respectively). After adjusting for potential confounders, NH Black patients continued to have greater odds of presenting with DKA compared with NH Whites (OR [95% CI]: 3.7 [1.4, 10.6]).

conclusionWe found that among T1D patients with COVID-19 infection, NH Black patients were more likely to present in DKA compared with NH White patients. Our findings demonstrate additional risk among NH Black patients with T1D and COVID-19.

Indexed as

Health Status DisparitiesAdolescentAdultBlack or African AmericanChildChild, PreschoolCOVID-19Cross-Sectional StudiesDiabetes Mellitus, Type 1Diabetic KetoacidosisFemaleHispanic or LatinoHumansMalePrevalencePrognosisCOVID-19DKAinequitiestype 1 diabetes

Identifiers

PMID33410917
PMCPMC7928931
OpenAlexW3119196898

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.