Evidence map›Paper›PMID 33410731›Full record

ArticleVirulence2021

Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain.

Rebeca Froes Rocha, Juliana L Del Sarto, Giovanni F Gomes, Mariana P Gonçalves, Milene A Rachid, Juliana H C Smetana, Daniele G Souza, Mauro Martins Teixeira, Rafael Elias Marques

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Competing interests during the keyFrontiers in chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rebeca Froes RochaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, Brazil.ORCID 0000-0002-5678-4006
Juliana L Del SartoImmunopharmacology Laboratory, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.ORCID 0000-0002-6561-8018
Giovanni F GomesLaboratório de Neurofarmacologia, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.
Mariana P GonçalvesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, Brazil.
Milene A RachidLaboratório de Apoptose, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.
Juliana H C SmetanaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, Brazil.
Daniele G SouzaLaboratório de Interação Microrganismo-Hospedeiro, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.
Mauro Martins TeixeiraImmunopharmacology Laboratory, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG) , Belo Horizonte, Brazil.
Rafael Elias MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM) , Campinas, Brazil.ORCID 0000-0002-6949-0947
Universidade Federal de Minas Gerais · BRBrazilian Center for Research in Energy and Materials · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in the CNS is not completely understood, which led us to characterize the roles of IFNs using mouse models of St. Louis encephalitis. We infected mice deficient in type I IFN receptor (ABR

Indexed as

AnimalsBrainDisease Models, AnimalEncephalitis, St. LouisEncephalitis Virus, St. LouisInterferon-gammaInterferon Type IMiceMice, Inbred C57BLViral LoadVirus ReplicationInterferon-gammaInterferon Type Iflavivirusinterferonsmouse modelNeglected arbovirusSt. Louis encephalitis

Identifiers

PMID33410731
PMCPMC7808420
OpenAlexW3118516848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.